DegronMD

Uniprot ID: Q14003

Source protein: Potassium voltage-gated channel subfamily C member 3

Source gene: KCNC3

Class: DEG_APCC_DBOX_1

Location: 102:110

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9941

ASA_SCORE: 58.5444

COIL: 0.3752

CONS_SCORE: 0.601

DSS_SCORE: 0.4393

HELIX: 0.5298

FCONS_SCORE: 1.1996

RIG_SCORE: 0.8048

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R98H	TCGA-JW-A69B	CESC	TCGA	YRSTLRTLP	DEG_APCC_DBOX_1	0.2222
p.R98H	DO49977	CESC	ICGC	YRSTLRTLP	DEG_APCC_DBOX_1	0.2222
p.P120T	DO230326	COCA	ICGC	YRSTLRTLP	DEG_APCC_DBOX_1	0.0556
p.P114L	DO233732	GACA	ICGC	YRSTLRTLP	DEG_APCC_DBOX_1	0.2222
p.P115L	DO228435	MALY	ICGC	YRSTLRTLP	DEG_APCC_DBOX_1	0.1944
p.S117F	DO232555	PBCA	ICGC	YRSTLRTLP	DEG_APCC_DBOX_1	0.1389
p.R107G	DO229499	SKCA	ICGC	YRSTLRTLP	DEG_APCC_DBOX_1	0.6457
p.T105M	DO229245	THCA	ICGC	YRSTLRTLP	DEG_APCC_DBOX_1	0.6312
p.L114M	SIDM00403	T-Lymphoblastic Leukemia	GDSC	YRSTLRTLP	DEG_APCC_DBOX_1	0.2222
p.L114M	ACH-000636	Leukemia	CCLE	YRSTLRTLP	DEG_APCC_DBOX_1	0.2222
p.Y102C	SIDM01007	T-Lymphoblastic Leukemia	GDSC	YRSTLRTLP	DEG_APCC_DBOX_1	0.7087
p.V97M	SIDM00946	T-Lymphoblastic Leukemia	GDSC	YRSTLRTLP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14003	Potassium voltage-gated channel subfamily C member 3	DEG_APCC_DBOX_1	102:110	YRSTLRTLP	APC,CDC20,FZR1	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons