DegronMD

Uniprot ID: Q96ES7

Source protein: SAGA-associated factor 29

Source gene: SGF29

Class: DEG_APCC_DBOX_1

Location: 55:63

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6222

ASA_SCORE: 55.7111

COIL: 0.0381

CONS_SCORE: 0.4384

DSS_SCORE: 0.2879

HELIX: 0.9601

FCONS_SCORE: 1.1757

RIG_SCORE: 0.8195

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R60C	SIDM01293	Colorectal Carcinoma	GDSC	YRTKLRGLY	DEG_APCC_DBOX_1	0.719
p.R60C	SIDM01088	Endometrial Carcinoma	GDSC	YRTKLRGLY	DEG_APCC_DBOX_1	0.719
p.R60C	RL95-2	endometrium	COSMIC	YRTKLRGLY	DEG_APCC_DBOX_1	0.719
p.R60H	SIDM00118	Colorectal Carcinoma	GDSC	YRTKLRGLY	DEG_APCC_DBOX_1	0.7133
p.R60H	HCC2998	large_intestine	COSMIC	YRTKLRGLY	DEG_APCC_DBOX_1	0.7133
p.A66T	SIDM01618	B-Lymphoblastic Leukemia	GDSC	YRTKLRGLY	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96ES7	SAGA-associated factor 29	DEG_APCC_DBOX_1	55:63	YRTKLRGLY	APC,CDC20,FZR1	0.6222	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons