DegronMD

Uniprot ID: Q9Y316

Source protein: Protein MEMO1

Source gene: MEMO1

Class: DEG_APCC_DBOX_1

Location: 96:104

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5153

ASA_SCORE: 52.1667

COIL: 0.325

CONS_SCORE: 0.6309

DSS_SCORE: 0.051

HELIX: 0.0046

FCONS_SCORE: 1.5611

RIG_SCORE: 0.911

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W114S	TCGA-24-1846	OV	TCGA	YRTPLYDLR	DEG_APCC_DBOX_1	0.0556
p.R104C	TCGA-AN-A046	BRCA	TCGA	YRTPLYDLR	DEG_APCC_DBOX_1	0.719
p.D102Y	TCGA-BS-A0TC	UCEC	TCGA	YRTPLYDLR	DEG_APCC_DBOX_1	0.6214
p.R104H	TCGA-BS-A0UV	UCEC	TCGA	YRTPLYDLR	DEG_APCC_DBOX_1	0.7133
p.R104H	TCGA-D1-A103	UCEC	TCGA	YRTPLYDLR	DEG_APCC_DBOX_1	0.7133
p.R104H	SIDM00951	T-Lymphoblastic Leukemia	GDSC	YRTPLYDLR	DEG_APCC_DBOX_1	0.7133
p.R104H	ACH-002222	Leukemia	CCLE	YRTPLYDLR	DEG_APCC_DBOX_1	0.7133
p.R104H	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	YRTPLYDLR	DEG_APCC_DBOX_1	0.7133
p.R104L	TCGA-D1-A16X	UCEC	TCGA	YRTPLYDLR	DEG_APCC_DBOX_1	0.7316
p.D106Y	TCGA-DK-A6AW	BLCA	TCGA	YRTPLYDLR	DEG_APCC_DBOX_1	0.2778
p.W91S	DO32718	OV	ICGC	YRTPLYDLR	DEG_APCC_DBOX_1	0.1944
p.K92E	SNU-182	liver	COSMIC	YRTPLYDLR	DEG_APCC_DBOX_1	0.2222
p.R107H	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	YRTPLYDLR	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y316	Protein MEMO1	DEG_APCC_DBOX_1	96:104	YRTPLYDLR	APC,CDC20,FZR1	0.5153	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons