DegronMD - P24385(CCND1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P287T	TCGA-AJ-A2QO	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7031
p.P287T	TCGA-JW-A5VH	CESC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7031
p.P287T	TCGA-VS-A9UJ	CESC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7031
p.P287T	DO219735	CESC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7031
p.P287T	DO51604	CESC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7031
p.P287T	DO42177	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7031
p.P287T	SIDM01612	Endometrial Carcinoma	GDSC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7031
p.P287T	ACH-000946	Endometrial/Uterine Cancer	CCLE	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7031
p.P287H	TCGA-AP-A1E1	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7694
p.P287H	TCGA-D1-A174	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7694
p.P287H	DO40900	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7694
p.P287H	DO43226	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7694
p.T286R	TCGA-AX-A2HG	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation blocking phosphorylation signal	0.75
p.T286R	DO41337	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation blocking phosphorylation signal	0.75
p.T286I	TCGA-B5-A0JV	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation blocking phosphorylation signal	0.75
p.T286I	TCGA-BG-A0M7	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation blocking phosphorylation signal	0.75
p.T286I	TCGA-D1-A0ZO	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation blocking phosphorylation signal	0.75
p.T286I	TCGA-D1-A163	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation blocking phosphorylation signal	0.75
p.T286I	TCGA-D1-A2G0	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation blocking phosphorylation signal	0.75
p.T286I	TCGA-PG-A6IB	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation blocking phosphorylation signal	0.75
p.T286I	DO42089	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation blocking phosphorylation signal	0.75
p.T286I	DO41008	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation blocking phosphorylation signal	0.75
p.T286I	DO43049	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation blocking phosphorylation signal	0.75
p.T286I	DO52419	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation blocking phosphorylation signal	0.75
p.T286I	DO41927	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation blocking phosphorylation signal	0.75
p.T286I	DO43979	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation blocking phosphorylation signal	0.75
p.P287L	TCGA-BA-A6DJ	HNSC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7582
p.P287L	TCGA-N7-A4Y0	UCS	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7582
p.P287L	DO222492	COCA	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7582
p.P287L	DO52034	HNSC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7582
p.P287L	SIDM00652	Small Cell Lung Carcinoma	GDSC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7582
p.P287L	ACH-000563	Lung Cancer	CCLE	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7582
p.P287L	ACH-000780	Lung Cancer	CCLE	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7582
p.P287L	NCI-H1105	lung	COSMIC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7582
p.V293G	TCGA-BS-A0U5	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7532
p.V293G	DO41975	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7532
p.V293G	DO230449	UTCA	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7532
p.V293G	ACH-000885	Ovarian Cancer	CCLE	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7532
p.D282H	TCGA-CV-6441	HNSC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation rewiring degron network	0.1944
p.D282H	DO14254	HNSC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation rewiring degron network	0.1944
p.P287S	TCGA-D1-A0ZU	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.6752
p.P287S	TCGA-D1-A17D	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.6752
p.P287S	TCGA-EO-A3KX	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.6752
p.P287S	DO233697	GACA	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.6752
p.P287S	DO219774	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.6752
p.P287S	DO41746	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.6752
p.P287S	DO41506	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.6752
p.V281E	TCGA-E6-A2P8	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation rewiring degron network	0.1667
p.V281E	DO40924	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation rewiring degron network	0.1667
p.T286A	TCGA-EO-A3AU	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation blocking phosphorylation signal	0.75
p.T286A	DO43827	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation blocking phosphorylation signal	0.75
p.P287R	TCGA-FD-A6TD	BLCA	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7512
p.P287R	DO49757	BLCA	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7512
p.P287R	SIDM00238	Ovarian Carcinoma	GDSC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7512
p.P287R	ACH-000947	Ovarian Cancer	CCLE	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7512
p.P287R	OVK-18	ovary	COSMIC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7512
p.V290M	TCGA-MO-A47R	SARC	TCGA	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7208
p.V290M	DO220221	SARC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7208
p.I295N	DO233612	GACA	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.728
p.D289N	DO233624	GACA	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.6932
p.E280D	DO229027	LICA	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation rewiring degron network	0.1389
p.P287A	DO42209	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7503
p.P287A	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7503
p.P287A	ACH-002311	Esophageal Cancer	CCLE	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7503
p.P287A	TE-12	oesophagus	COSMIC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7503
p.E280V	SIDM00373	Endometrial Carcinoma	GDSC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation rewiring degron network	0.1389
p.E280V	ACH-000974	Endometrial/Uterine Cancer	CCLE	PTDVRDVDI	SCF_FBXO31	287:295	Mutation rewiring degron network	0.1389
p.R291W	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7523
p.R291W	NCI-H1435	lung	COSMIC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7523
p.R291L	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7316
p.R291L	ACH-000852	Lung Cancer	CCLE	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7316
p.R291L	NCI-H1435	lung	COSMIC	PTDVRDVDI	SCF_FBXO31	287:295	Mutation altering degron motif	0.7316

Kaplan plot for CCND1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCND1

UniProt ID: P24385

Entrez ID: 595

Protein name: G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCND1 in