DegronMD

Uniprot ID: P24385

Source protein: G1/S-specific cyclin-D1

Source gene: CCND1

Class: SCF_FBXO31

Location: 287:295

E3 ligase: FBXO31

DEGRON score: 0.996

ASA_SCORE: 69.1889

COIL: 0.6637

CONS_SCORE: 0.3884

DSS_SCORE: 0.8232

HELIX: 0.1201

FCONS_SCORE: 1.174

RIG_SCORE: 0.8051

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P287T	TCGA-AJ-A2QO	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	0.7031
p.P287T	TCGA-JW-A5VH	CESC	TCGA	PTDVRDVDI	SCF_FBXO31	0.7031
p.P287T	TCGA-VS-A9UJ	CESC	TCGA	PTDVRDVDI	SCF_FBXO31	0.7031
p.P287T	DO219735	CESC	ICGC	PTDVRDVDI	SCF_FBXO31	0.7031
p.P287T	DO51604	CESC	ICGC	PTDVRDVDI	SCF_FBXO31	0.7031
p.P287T	DO42177	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	0.7031
p.P287T	SIDM01612	Endometrial Carcinoma	GDSC	PTDVRDVDI	SCF_FBXO31	0.7031
p.P287T	ACH-000946	Endometrial/Uterine Cancer	CCLE	PTDVRDVDI	SCF_FBXO31	0.7031
p.P287H	TCGA-AP-A1E1	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	0.7694
p.P287H	TCGA-D1-A174	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	0.7694
p.P287H	DO40900	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	0.7694
p.P287H	DO43226	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	0.7694
p.T286R	TCGA-AX-A2HG	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	0.75
p.T286R	DO41337	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	0.75
p.T286I	TCGA-B5-A0JV	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	0.75
p.T286I	TCGA-BG-A0M7	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	0.75
p.T286I	TCGA-D1-A0ZO	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	0.75
p.T286I	TCGA-D1-A163	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	0.75
p.T286I	TCGA-D1-A2G0	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	0.75
p.T286I	TCGA-PG-A6IB	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	0.75
p.T286I	DO42089	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	0.75
p.T286I	DO41008	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	0.75
p.T286I	DO43049	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	0.75
p.T286I	DO52419	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	0.75
p.T286I	DO41927	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	0.75
p.T286I	DO43979	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	0.75
p.P287L	TCGA-BA-A6DJ	HNSC	TCGA	PTDVRDVDI	SCF_FBXO31	0.7582
p.P287L	TCGA-N7-A4Y0	UCS	TCGA	PTDVRDVDI	SCF_FBXO31	0.7582
p.P287L	DO222492	COCA	ICGC	PTDVRDVDI	SCF_FBXO31	0.7582
p.P287L	DO52034	HNSC	ICGC	PTDVRDVDI	SCF_FBXO31	0.7582
p.P287L	SIDM00652	Small Cell Lung Carcinoma	GDSC	PTDVRDVDI	SCF_FBXO31	0.7582
p.P287L	ACH-000563	Lung Cancer	CCLE	PTDVRDVDI	SCF_FBXO31	0.7582
p.P287L	ACH-000780	Lung Cancer	CCLE	PTDVRDVDI	SCF_FBXO31	0.7582
p.P287L	NCI-H1105	lung	COSMIC	PTDVRDVDI	SCF_FBXO31	0.7582
p.V293G	TCGA-BS-A0U5	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	0.7532
p.V293G	DO41975	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	0.7532
p.V293G	DO230449	UTCA	ICGC	PTDVRDVDI	SCF_FBXO31	0.7532
p.V293G	ACH-000885	Ovarian Cancer	CCLE	PTDVRDVDI	SCF_FBXO31	0.7532
p.D282H	TCGA-CV-6441	HNSC	TCGA	PTDVRDVDI	SCF_FBXO31	0.1944
p.D282H	DO14254	HNSC	ICGC	PTDVRDVDI	SCF_FBXO31	0.1944
p.P287S	TCGA-D1-A0ZU	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	0.6752
p.P287S	TCGA-D1-A17D	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	0.6752
p.P287S	TCGA-EO-A3KX	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	0.6752
p.P287S	DO233697	GACA	ICGC	PTDVRDVDI	SCF_FBXO31	0.6752
p.P287S	DO219774	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	0.6752
p.P287S	DO41746	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	0.6752
p.P287S	DO41506	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	0.6752
p.V281E	TCGA-E6-A2P8	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	0.1667
p.V281E	DO40924	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	0.1667
p.T286A	TCGA-EO-A3AU	UCEC	TCGA	PTDVRDVDI	SCF_FBXO31	0.75
p.T286A	DO43827	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	0.75
p.P287R	TCGA-FD-A6TD	BLCA	TCGA	PTDVRDVDI	SCF_FBXO31	0.7512
p.P287R	DO49757	BLCA	ICGC	PTDVRDVDI	SCF_FBXO31	0.7512
p.P287R	SIDM00238	Ovarian Carcinoma	GDSC	PTDVRDVDI	SCF_FBXO31	0.7512
p.P287R	ACH-000947	Ovarian Cancer	CCLE	PTDVRDVDI	SCF_FBXO31	0.7512
p.P287R	OVK-18	ovary	COSMIC	PTDVRDVDI	SCF_FBXO31	0.7512
p.V290M	TCGA-MO-A47R	SARC	TCGA	PTDVRDVDI	SCF_FBXO31	0.7208
p.V290M	DO220221	SARC	ICGC	PTDVRDVDI	SCF_FBXO31	0.7208
p.I295N	DO233612	GACA	ICGC	PTDVRDVDI	SCF_FBXO31	0.728
p.D289N	DO233624	GACA	ICGC	PTDVRDVDI	SCF_FBXO31	0.6932
p.E280D	DO229027	LICA	ICGC	PTDVRDVDI	SCF_FBXO31	0.1389
p.P287A	DO42209	UCEC	ICGC	PTDVRDVDI	SCF_FBXO31	0.7503
p.P287A	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	PTDVRDVDI	SCF_FBXO31	0.7503
p.P287A	ACH-002311	Esophageal Cancer	CCLE	PTDVRDVDI	SCF_FBXO31	0.7503
p.P287A	TE-12	oesophagus	COSMIC	PTDVRDVDI	SCF_FBXO31	0.7503
p.E280V	SIDM00373	Endometrial Carcinoma	GDSC	PTDVRDVDI	SCF_FBXO31	0.1389
p.E280V	ACH-000974	Endometrial/Uterine Cancer	CCLE	PTDVRDVDI	SCF_FBXO31	0.1389
p.R291W	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	PTDVRDVDI	SCF_FBXO31	0.7523
p.R291W	NCI-H1435	lung	COSMIC	PTDVRDVDI	SCF_FBXO31	0.7523
p.R291L	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	PTDVRDVDI	SCF_FBXO31	0.7316
p.R291L	ACH-000852	Lung Cancer	CCLE	PTDVRDVDI	SCF_FBXO31	0.7316
p.R291L	NCI-H1435	lung	COSMIC	PTDVRDVDI	SCF_FBXO31	0.7316

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTDVRDVDI

Degron related mutations and impact score

Drug responses associated with CCND1 mutations

All proteins holding degron of PTDVRDVDI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P24385	G1/S-specific cyclin-D1	SCF_FBXO31	287:295	PTDVRDVDI	FBXO31	0.996	More...