DegronMD - P30279(CCND2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R285W	TCGA-AP-A0LM	UCEC	TCGA	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.7523
p.R285W	TCGA-DK-A6B2	BLCA	TCGA	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.7523
p.R285W	TCGA-FR-A7U8	SKCM	TCGA	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.7523
p.R285W	DO48543	BLCA	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.7523
p.R285W	DO48683	SKCM	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.7523
p.R285W	DO43306	UCEC	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.7523
p.D273N	TCGA-D3-A5GO	SKCM	TCGA	PTDVRDIDL	SCF_FBXO31	281:289	Mutation rewiring degron network	0.1111
p.D273N	DO47419	SKCM	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation rewiring degron network	0.1111
p.E272D	TCGA-E6-A1LX	UCEC	TCGA	PTDVRDIDL	SCF_FBXO31	281:289	Mutation rewiring degron network	0.0833
p.E272D	DO41020	UCEC	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation rewiring degron network	0.0833
p.R285Q	TCGA-FI-A2D5	UCEC	TCGA	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.6218
p.R285Q	DO41331	UCEC	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.6218
p.R285Q	SIDM00006	Other Solid Cancers	GDSC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.6218
p.R285Q	MCC26	skin	COSMIC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.6218
p.S271L	TCGA-YD-A9TA	SKCM	TCGA	PTDVRDIDL	SCF_FBXO31	281:289	Mutation blocking phosphorylation signal	0.5
p.S271L	DO219503	SKCM	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation blocking phosphorylation signal	0.5
p.S271L	SIDM00444	Esophageal Carcinoma	GDSC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation blocking phosphorylation signal	0.5
p.S271L	ACH-001368	Esophageal Cancer	CCLE	PTDVRDIDL	SCF_FBXO31	281:289	Mutation blocking phosphorylation signal	0.5
p.S271L	OACM5-1	oesophagus	COSMIC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation blocking phosphorylation signal	0.5
p.L289P	DO49342	ALL	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.7582
p.P281S	DO221161	AML	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.6752
p.P281S	DO229512	LAML	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.6752
p.V284E	DO221186	AML	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.7693
p.V284E	DO227513	LAML	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.7693
p.T280N	DO221237	AML	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation blocking phosphorylation signal	0.75
p.T280N	DO225409	LAML	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation blocking phosphorylation signal	0.75
p.T280N	DO225428	LAML	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation blocking phosphorylation signal	0.75
p.T280I	DO223388	CLLE	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation blocking phosphorylation signal	0.75
p.P281T	DO6712	CLLE	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.7031
p.P281R	DO6568	CLLE	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.7512
p.P281R	DO6364	CLLE	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.7512
p.P281R	DO52011	CLLE	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.7512
p.D276Y	DO229027	LICA	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation rewiring degron network	0.1944
p.V284L	DO229037	LICA	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.6765
p.V284L	SIDM00383	Gastric Carcinoma	GDSC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.6765
p.V284L	ACH-002198	Gastric Cancer	CCLE	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.6765
p.V284L	SCH	stomach	COSMIC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.6765
p.T280A	DO48904	PBCA	ICGC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation blocking phosphorylation signal	0.75
p.V284M	SIDM00841	Colorectal Carcinoma	GDSC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.7208
p.V284M	ACH-000651	Colon/Colorectal Cancer	CCLE	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.7208
p.V284M	SW620	large intestine	COSMIC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.7208
p.P281A	SIDM01193	Glioma	GDSC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.7503
p.P281A	ACH-000040	Brain Cancer	CCLE	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.7503
p.P281A	ACH-001214	Brain Cancer	CCLE	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.7503
p.P281A	U-118-MG	central nervous system	COSMIC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation altering degron motif	0.7503
p.A278T	SIDM00217	Colorectal Carcinoma	GDSC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation rewiring degron network	0.25
p.A278T	ACH-000999	Colon/Colorectal Cancer	CCLE	PTDVRDIDL	SCF_FBXO31	281:289	Mutation rewiring degron network	0.25
p.A278T	SNU-1040	large intestine	COSMIC	PTDVRDIDL	SCF_FBXO31	281:289	Mutation rewiring degron network	0.25

Kaplan plot for CCND2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCND2

UniProt ID: P30279

Entrez ID: 894

Protein name: G1/S-specific cyclin-D2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCND2 in