DegronMD

Uniprot ID: P30279

Source protein: G1/S-specific cyclin-D2

Source gene: CCND2

Class: SCF_FBXO31

Location: 281:289

E3 ligase: FBXO31

DEGRON score: 0.9883

ASA_SCORE: 67.3667

COIL: 0.667

CONS_SCORE: 0.4914

DSS_SCORE: 0.8603

HELIX: 0.1276

FCONS_SCORE: 1.1222

RIG_SCORE: 0.7579

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R285W	TCGA-AP-A0LM	UCEC	TCGA	PTDVRDIDL	SCF_FBXO31	0.7523
p.R285W	TCGA-DK-A6B2	BLCA	TCGA	PTDVRDIDL	SCF_FBXO31	0.7523
p.R285W	TCGA-FR-A7U8	SKCM	TCGA	PTDVRDIDL	SCF_FBXO31	0.7523
p.R285W	DO48543	BLCA	ICGC	PTDVRDIDL	SCF_FBXO31	0.7523
p.R285W	DO48683	SKCM	ICGC	PTDVRDIDL	SCF_FBXO31	0.7523
p.R285W	DO43306	UCEC	ICGC	PTDVRDIDL	SCF_FBXO31	0.7523
p.D273N	TCGA-D3-A5GO	SKCM	TCGA	PTDVRDIDL	SCF_FBXO31	0.1111
p.D273N	DO47419	SKCM	ICGC	PTDVRDIDL	SCF_FBXO31	0.1111
p.E272D	TCGA-E6-A1LX	UCEC	TCGA	PTDVRDIDL	SCF_FBXO31	0.0833
p.E272D	DO41020	UCEC	ICGC	PTDVRDIDL	SCF_FBXO31	0.0833
p.R285Q	TCGA-FI-A2D5	UCEC	TCGA	PTDVRDIDL	SCF_FBXO31	0.6218
p.R285Q	DO41331	UCEC	ICGC	PTDVRDIDL	SCF_FBXO31	0.6218
p.R285Q	SIDM00006	Other Solid Cancers	GDSC	PTDVRDIDL	SCF_FBXO31	0.6218
p.R285Q	MCC26	skin	COSMIC	PTDVRDIDL	SCF_FBXO31	0.6218
p.S271L	TCGA-YD-A9TA	SKCM	TCGA	PTDVRDIDL	SCF_FBXO31	0.5
p.S271L	DO219503	SKCM	ICGC	PTDVRDIDL	SCF_FBXO31	0.5
p.S271L	SIDM00444	Esophageal Carcinoma	GDSC	PTDVRDIDL	SCF_FBXO31	0.5
p.S271L	ACH-001368	Esophageal Cancer	CCLE	PTDVRDIDL	SCF_FBXO31	0.5
p.S271L	OACM5-1	oesophagus	COSMIC	PTDVRDIDL	SCF_FBXO31	0.5
p.L289P	DO49342	ALL	ICGC	PTDVRDIDL	SCF_FBXO31	0.7582
p.P281S	DO221161	AML	ICGC	PTDVRDIDL	SCF_FBXO31	0.6752
p.P281S	DO229512	LAML	ICGC	PTDVRDIDL	SCF_FBXO31	0.6752
p.V284E	DO221186	AML	ICGC	PTDVRDIDL	SCF_FBXO31	0.7693
p.V284E	DO227513	LAML	ICGC	PTDVRDIDL	SCF_FBXO31	0.7693
p.T280N	DO221237	AML	ICGC	PTDVRDIDL	SCF_FBXO31	0.75
p.T280N	DO225409	LAML	ICGC	PTDVRDIDL	SCF_FBXO31	0.75
p.T280N	DO225428	LAML	ICGC	PTDVRDIDL	SCF_FBXO31	0.75
p.T280I	DO223388	CLLE	ICGC	PTDVRDIDL	SCF_FBXO31	0.75
p.P281T	DO6712	CLLE	ICGC	PTDVRDIDL	SCF_FBXO31	0.7031
p.P281R	DO6568	CLLE	ICGC	PTDVRDIDL	SCF_FBXO31	0.7512
p.P281R	DO6364	CLLE	ICGC	PTDVRDIDL	SCF_FBXO31	0.7512
p.P281R	DO52011	CLLE	ICGC	PTDVRDIDL	SCF_FBXO31	0.7512
p.D276Y	DO229027	LICA	ICGC	PTDVRDIDL	SCF_FBXO31	0.1944
p.V284L	DO229037	LICA	ICGC	PTDVRDIDL	SCF_FBXO31	0.6765
p.V284L	SIDM00383	Gastric Carcinoma	GDSC	PTDVRDIDL	SCF_FBXO31	0.6765
p.V284L	ACH-002198	Gastric Cancer	CCLE	PTDVRDIDL	SCF_FBXO31	0.6765
p.V284L	SCH	stomach	COSMIC	PTDVRDIDL	SCF_FBXO31	0.6765
p.T280A	DO48904	PBCA	ICGC	PTDVRDIDL	SCF_FBXO31	0.75
p.V284M	SIDM00841	Colorectal Carcinoma	GDSC	PTDVRDIDL	SCF_FBXO31	0.7208
p.V284M	ACH-000651	Colon/Colorectal Cancer	CCLE	PTDVRDIDL	SCF_FBXO31	0.7208
p.V284M	SW620	large_intestine	COSMIC	PTDVRDIDL	SCF_FBXO31	0.7208
p.P281A	SIDM01193	Glioma	GDSC	PTDVRDIDL	SCF_FBXO31	0.7503
p.P281A	ACH-000040	Brain Cancer	CCLE	PTDVRDIDL	SCF_FBXO31	0.7503
p.P281A	ACH-001214	Brain Cancer	CCLE	PTDVRDIDL	SCF_FBXO31	0.7503
p.P281A	U-118-MG	central_nervous_system	COSMIC	PTDVRDIDL	SCF_FBXO31	0.7503
p.A278T	SIDM00217	Colorectal Carcinoma	GDSC	PTDVRDIDL	SCF_FBXO31	0.25
p.A278T	ACH-000999	Colon/Colorectal Cancer	CCLE	PTDVRDIDL	SCF_FBXO31	0.25
p.A278T	SNU-1040	large_intestine	COSMIC	PTDVRDIDL	SCF_FBXO31	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTDVRDIDL

Degron related mutations and impact score

Drug responses associated with CCND2 mutations

All proteins holding degron of PTDVRDIDL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30279	G1/S-specific cyclin-D2	SCF_FBXO31	281:289	PTDVRDIDL	FBXO31	0.9883	More...