DegronMD - P30281(CCND3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V287I	TCGA-D1-A163	UCEC	TCGA	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7076
p.P278R	TCGA-E2-A1IE	BRCA	TCGA	PTDVTAIHL	SCF_FBXO31	284:292	Mutation rewiring degron network	0.1667
p.T283A	TCGA-GS-A9TU	DLBC	TCGA	PTDVTAIHL	SCF_FBXO31	284:292	Mutation blocking phosphorylation signal	0.75
p.T283A	DO7018	CLLE	ICGC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation blocking phosphorylation signal	0.75
p.T283A	DO219913	DLBC	ICGC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation blocking phosphorylation signal	0.75
p.T283A	ACH-001617	Lymphoma	CCLE	PTDVTAIHL	SCF_FBXO31	284:292	Mutation blocking phosphorylation signal	0.75
p.A289D	DO228974	LICA	ICGC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.6682
p.I290K	DO27829	MALY	ICGC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7531
p.I290K	DO27765	MALY	ICGC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7531
p.I290K	DO228600	MALY	ICGC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7531
p.I290K	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7531
p.I290K	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7531
p.I290K	SIDM01177	B-Lymphoblastic Leukemia	GDSC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7531
p.I290K	ACH-000157	Lymphoma	CCLE	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7531
p.I290K	ACH-001703	Lymphoma	CCLE	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7531
p.I290K	ACH-002272	Lymphoma	CCLE	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7531
p.I290K	ACH-002308	Leukemia	CCLE	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7531
p.I290T	DO52685	MALY	ICGC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7078
p.I290T	SIDM00389	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7078
p.I290T	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7078
p.I290T	SIDM01424	B-Lymphoblastic Leukemia	GDSC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7078
p.I290T	ACH-000056	Lymphoma	CCLE	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7078
p.I290T	ACH-000271	Lymphoma	CCLE	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7078
p.I290T	ACH-000782	Leukemia	CCLE	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7078
p.I290T	ACH-001735	Leukemia	CCLE	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7078
p.T283P	DO228882	MALY	ICGC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation blocking phosphorylation signal	0.75
p.T283P	DO221117	MALY	ICGC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation blocking phosphorylation signal	0.75
p.D286A	DO231284	PACA	ICGC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7793
p.P284L	SIDM01198	Burkitt's Lymphoma	GDSC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7582
p.P284L	ACH-000567	Lymphoma	CCLE	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7582
p.T283I	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation blocking phosphorylation signal	0.75
p.T283I	ACH-002059	Leukemia	CCLE	PTDVTAIHL	SCF_FBXO31	284:292	Mutation blocking phosphorylation signal	0.75
p.T283I	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation blocking phosphorylation signal	0.75
p.I290R	SIDM00854	Burkitt's Lymphoma	GDSC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.8102
p.I290R	ACH-000162	Lymphoma	CCLE	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.8102
p.I290R	ACH-001450	Lymphoma	CCLE	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.8102
p.P284S	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.6752
p.P284S	ACH-000388	Lymphoma	CCLE	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.6752
p.V287D	ACH-000405	Leukemia	CCLE	PTDVTAIHL	SCF_FBXO31	284:292	Mutation altering degron motif	0.7785

Kaplan plot for CCND3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCND3

UniProt ID: P30281

Entrez ID: 896

Protein name: G1/S-specific cyclin-D3

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CCND3 in