DegronMD

Uniprot ID: P30281

Source protein: G1/S-specific cyclin-D3

Source gene: CCND3

Class: SCF_FBXO31

Location: 284:292

E3 ligase: FBXO31

DEGRON score: 0.9928

ASA_SCORE: 67.6778

COIL: 0.6794

CONS_SCORE: 0.3578

DSS_SCORE: 0.9095

HELIX: 0.1921

FCONS_SCORE: 1.0551

RIG_SCORE: 0.734

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V287I	TCGA-D1-A163	UCEC	TCGA	PTDVTAIHL	SCF_FBXO31	0.7076
p.P278R	TCGA-E2-A1IE	BRCA	TCGA	PTDVTAIHL	SCF_FBXO31	0.1667
p.T283A	TCGA-GS-A9TU	DLBC	TCGA	PTDVTAIHL	SCF_FBXO31	0.75
p.T283A	DO7018	CLLE	ICGC	PTDVTAIHL	SCF_FBXO31	0.75
p.T283A	DO219913	DLBC	ICGC	PTDVTAIHL	SCF_FBXO31	0.75
p.T283A	ACH-001617	Lymphoma	CCLE	PTDVTAIHL	SCF_FBXO31	0.75
p.A289D	DO228974	LICA	ICGC	PTDVTAIHL	SCF_FBXO31	0.6682
p.I290K	DO27829	MALY	ICGC	PTDVTAIHL	SCF_FBXO31	0.7531
p.I290K	DO27765	MALY	ICGC	PTDVTAIHL	SCF_FBXO31	0.7531
p.I290K	DO228600	MALY	ICGC	PTDVTAIHL	SCF_FBXO31	0.7531
p.I290K	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTDVTAIHL	SCF_FBXO31	0.7531
p.I290K	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTDVTAIHL	SCF_FBXO31	0.7531
p.I290K	SIDM01177	B-Lymphoblastic Leukemia	GDSC	PTDVTAIHL	SCF_FBXO31	0.7531
p.I290K	ACH-000157	Lymphoma	CCLE	PTDVTAIHL	SCF_FBXO31	0.7531
p.I290K	ACH-001703	Lymphoma	CCLE	PTDVTAIHL	SCF_FBXO31	0.7531
p.I290K	ACH-002272	Lymphoma	CCLE	PTDVTAIHL	SCF_FBXO31	0.7531
p.I290K	ACH-002308	Leukemia	CCLE	PTDVTAIHL	SCF_FBXO31	0.7531
p.I290T	DO52685	MALY	ICGC	PTDVTAIHL	SCF_FBXO31	0.7078
p.I290T	SIDM00389	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTDVTAIHL	SCF_FBXO31	0.7078
p.I290T	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTDVTAIHL	SCF_FBXO31	0.7078
p.I290T	SIDM01424	B-Lymphoblastic Leukemia	GDSC	PTDVTAIHL	SCF_FBXO31	0.7078
p.I290T	ACH-000056	Lymphoma	CCLE	PTDVTAIHL	SCF_FBXO31	0.7078
p.I290T	ACH-000271	Lymphoma	CCLE	PTDVTAIHL	SCF_FBXO31	0.7078
p.I290T	ACH-000782	Leukemia	CCLE	PTDVTAIHL	SCF_FBXO31	0.7078
p.I290T	ACH-001735	Leukemia	CCLE	PTDVTAIHL	SCF_FBXO31	0.7078
p.T283P	DO228882	MALY	ICGC	PTDVTAIHL	SCF_FBXO31	0.75
p.T283P	DO221117	MALY	ICGC	PTDVTAIHL	SCF_FBXO31	0.75
p.D286A	DO231284	PACA	ICGC	PTDVTAIHL	SCF_FBXO31	0.7793
p.P284L	SIDM01198	Burkitt's Lymphoma	GDSC	PTDVTAIHL	SCF_FBXO31	0.7582
p.P284L	ACH-000567	Lymphoma	CCLE	PTDVTAIHL	SCF_FBXO31	0.7582
p.T283I	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PTDVTAIHL	SCF_FBXO31	0.75
p.T283I	ACH-002059	Leukemia	CCLE	PTDVTAIHL	SCF_FBXO31	0.75
p.T283I	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	PTDVTAIHL	SCF_FBXO31	0.75
p.I290R	SIDM00854	Burkitt's Lymphoma	GDSC	PTDVTAIHL	SCF_FBXO31	0.8102
p.I290R	ACH-000162	Lymphoma	CCLE	PTDVTAIHL	SCF_FBXO31	0.8102
p.I290R	ACH-001450	Lymphoma	CCLE	PTDVTAIHL	SCF_FBXO31	0.8102
p.P284S	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTDVTAIHL	SCF_FBXO31	0.6752
p.P284S	ACH-000388	Lymphoma	CCLE	PTDVTAIHL	SCF_FBXO31	0.6752
p.V287D	ACH-000405	Leukemia	CCLE	PTDVTAIHL	SCF_FBXO31	0.7785

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTDVTAIHL

Degron related mutations and impact score

Drug responses associated with CCND3 mutations

All proteins holding degron of PTDVTAIHL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30281	G1/S-specific cyclin-D3	SCF_FBXO31	284:292	PTDVTAIHL	FBXO31	0.9928	More...