DegronMD - P57052(RBM11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A204S	TCGA-17-Z033	LUAD	TCGA	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.0833
p.L206F	TCGA-AP-A056	UCEC	TCGA	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.1389
p.L206F	DO43971	UCEC	ICGC	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.1389
p.P207T	TCGA-AX-A05Z	UCEC	TCGA	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.1667
p.P207T	DO40884	UCEC	ICGC	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.1667
p.H176R	TCGA-B0-5098	KIRC	TCGA	SSSLNHVPDL	DEG_COP1_1	171:180	Mutation altering degron motif	0.7133
p.H176R	DO18938	KIRC	ICGC	SSSLNHVPDL	DEG_COP1_1	171:180	Mutation altering degron motif	0.7133
p.G225A	TCGA-CV-6945	HNSC	TCGA	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.25
p.G225A	DO15767	HNSC	ICGC	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.25
p.A204T	TCGA-DH-5140	LGG	TCGA	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.0833
p.A204T	DO22701	LGG	ICGC	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.0833
p.P207S	TCGA-DX-AB2E	SARC	TCGA	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.1667
p.P207S	DO220073	SARC	ICGC	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.1667
p.D179E	TCGA-EB-A6R0	SKCM	TCGA	SSSLNHVPDL	DEG_COP1_1	171:180	Mutation altering degron motif	0.5647
p.D179E	DO48646	SKCM	ICGC	SSSLNHVPDL	DEG_COP1_1	171:180	Mutation altering degron motif	0.5647
p.L180F	TCGA-EB-A6R0	SKCM	TCGA	SSSLNHVPDL	DEG_COP1_1	171:180	Mutation altering degron motif	0.587
p.L180F	DO222662	MELA	ICGC	SSSLNHVPDL	DEG_COP1_1	171:180	Mutation altering degron motif	0.587
p.L180F	DO48646	SKCM	ICGC	SSSLNHVPDL	DEG_COP1_1	171:180	Mutation altering degron motif	0.587
p.S228L	TCGA-EE-A29H	SKCM	TCGA	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.1667
p.S228L	DO37535	SKCM	ICGC	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.1667
p.G183R	TCGA-EE-A29S	SKCM	TCGA	SSSLNHVPDL	DEG_COP1_1	171:180	Mutation rewiring degron network	0.25
p.G183R	DO37936	SKCM	ICGC	SSSLNHVPDL	DEG_COP1_1	171:180	Mutation rewiring degron network	0.25
p.S214F	TCGA-EE-A2M5	SKCM	TCGA	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation altering degron motif	0.6871
p.S214F	DO222423	MELA	ICGC	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation altering degron motif	0.6871
p.S214F	DO37425	SKCM	ICGC	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation altering degron motif	0.6871
p.D179Y	TCGA-F9-A4JJ	KIRP	TCGA	SSSLNHVPDL	DEG_COP1_1	171:180	Mutation altering degron motif	0.7325
p.D179Y	DO48472	KIRP	ICGC	SSSLNHVPDL	DEG_COP1_1	171:180	Mutation altering degron motif	0.7325
p.S173L	TCGA-FW-A3R5	SKCM	TCGA	SSSLNHVPDL	DEG_COP1_1	171:180	Mutation altering degron motif	0.7667
p.S173L	DO37406	SKCM	ICGC	SSSLNHVPDL	DEG_COP1_1	171:180	Mutation altering degron motif	0.7667
p.G225R	TCGA-GN-A26C	SKCM	TCGA	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.25
p.G225R	DO37782	SKCM	ICGC	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.25
p.P205L	DO48372	BLCA	ICGC	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.1111
p.P226L	DO229050	LICA	ICGC	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.2222
p.H218L	DO50897	LICA	ICGC	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation altering degron motif	0.6202
p.E181Q	DO224566	LUSC	ICGC	SSSLNHVPDL	DEG_COP1_1	171:180	Mutation rewiring degron network	0.3056
p.E181Q	DO231007	LUSC	ICGC	SSSLNHVPDL	DEG_COP1_1	171:180	Mutation rewiring degron network	0.3056
p.P178L	DO222363	MELA	ICGC	SSSLNHVPDL	DEG_COP1_1	171:180	Mutation altering degron motif	0.7582
p.S211F	DO222868	MELA	ICGC	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.2778
p.L222F	DO222880	MELA	ICGC	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation altering degron motif	0.587
p.P165S	SIDM00545	Melanoma	GDSC	SSSLNHVPDL	DEG_COP1_1	171:180	Mutation rewiring degron network	0.1667
p.P165S	ACH-000987	Skin Cancer	CCLE	SSSLNHVPDL	DEG_COP1_1	171:180	Mutation rewiring degron network	0.1667
p.P165S	Mewo	skin	COSMIC	SSSLNHVPDL	DEG_COP1_1	171:180	Mutation rewiring degron network	0.1667
p.S211P	SIDM01588	Endometrial Carcinoma	GDSC	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.2778
p.S211P	ACH-000993	Endometrial/Uterine Cancer	CCLE	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.2778
p.A224T	ACH-000967	Colon/Colorectal Cancer	CCLE	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.2778
p.A224T	ACH-001199	Colon/Colorectal Cancer	CCLE	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.2778
p.A224T	SNU-C2B	large intestine	COSMIC	SSSLNHVPDL	DEG_COP1_1	213:222	Mutation rewiring degron network	0.2778

Kaplan plot for RBM11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBM11

UniProt ID: P57052

Entrez ID: 54033

Protein name: Splicing regulator RBM11 (RNA-binding motif protein 11)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBM11 in