DegronMD

Uniprot ID: P57052

Source protein: Splicing regulator RBM11

Source gene: RBM11

Class: DEG_COP1_1

Location: 171:180

E3 ligase: COP1

DEGRON score: 0.9833

ASA_SCORE: 68.97

COIL: 0.9151

CONS_SCORE: 0.3949

DSS_SCORE: 0.459

HELIX: 0.0578

FCONS_SCORE: 1.049

RIG_SCORE: 0.6632

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H176R	TCGA-B0-5098	KIRC	TCGA	SSSLNHVPDL	DEG_COP1_1	0.7133
p.H176R	DO18938	KIRC	ICGC	SSSLNHVPDL	DEG_COP1_1	0.7133
p.D179E	TCGA-EB-A6R0	SKCM	TCGA	SSSLNHVPDL	DEG_COP1_1	0.5647
p.D179E	DO48646	SKCM	ICGC	SSSLNHVPDL	DEG_COP1_1	0.5647
p.L180F	TCGA-EB-A6R0	SKCM	TCGA	SSSLNHVPDL	DEG_COP1_1	0.587
p.L180F	DO222662	MELA	ICGC	SSSLNHVPDL	DEG_COP1_1	0.587
p.L180F	DO48646	SKCM	ICGC	SSSLNHVPDL	DEG_COP1_1	0.587
p.G183R	TCGA-EE-A29S	SKCM	TCGA	SSSLNHVPDL	DEG_COP1_1	0.25
p.G183R	DO37936	SKCM	ICGC	SSSLNHVPDL	DEG_COP1_1	0.25
p.D179Y	TCGA-F9-A4JJ	KIRP	TCGA	SSSLNHVPDL	DEG_COP1_1	0.7325
p.D179Y	DO48472	KIRP	ICGC	SSSLNHVPDL	DEG_COP1_1	0.7325
p.S173L	TCGA-FW-A3R5	SKCM	TCGA	SSSLNHVPDL	DEG_COP1_1	0.7667
p.S173L	DO37406	SKCM	ICGC	SSSLNHVPDL	DEG_COP1_1	0.7667
p.E181Q	DO224566	LUSC	ICGC	SSSLNHVPDL	DEG_COP1_1	0.3056
p.E181Q	DO231007	LUSC	ICGC	SSSLNHVPDL	DEG_COP1_1	0.3056
p.P178L	DO222363	MELA	ICGC	SSSLNHVPDL	DEG_COP1_1	0.7582
p.P165S	SIDM00545	Melanoma	GDSC	SSSLNHVPDL	DEG_COP1_1	0.1667
p.P165S	ACH-000987	Skin Cancer	CCLE	SSSLNHVPDL	DEG_COP1_1	0.1667
p.P165S	Mewo	skin	COSMIC	SSSLNHVPDL	DEG_COP1_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons