DegronMD

Uniprot ID: P57052

Source protein: Splicing regulator RBM11

Source gene: RBM11

Class: DEG_COP1_1

Location: 213:222

E3 ligase: COP1

DEGRON score: 0.9197

ASA_SCORE: 83.94

COIL: 0.9106

CONS_SCORE: 0.1471

DSS_SCORE: 0.5249

HELIX: 0.0751

FCONS_SCORE: 0.7744

RIG_SCORE: 0.6387

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A204S	TCGA-17-Z033	LUAD	TCGA	SSSLNHVPDL	DEG_COP1_1	0.0833
p.L206F	TCGA-AP-A056	UCEC	TCGA	SSSLNHVPDL	DEG_COP1_1	0.1389
p.L206F	DO43971	UCEC	ICGC	SSSLNHVPDL	DEG_COP1_1	0.1389
p.P207T	TCGA-AX-A05Z	UCEC	TCGA	SSSLNHVPDL	DEG_COP1_1	0.1667
p.P207T	DO40884	UCEC	ICGC	SSSLNHVPDL	DEG_COP1_1	0.1667
p.G225A	TCGA-CV-6945	HNSC	TCGA	SSSLNHVPDL	DEG_COP1_1	0.25
p.G225A	DO15767	HNSC	ICGC	SSSLNHVPDL	DEG_COP1_1	0.25
p.A204T	TCGA-DH-5140	LGG	TCGA	SSSLNHVPDL	DEG_COP1_1	0.0833
p.A204T	DO22701	LGG	ICGC	SSSLNHVPDL	DEG_COP1_1	0.0833
p.P207S	TCGA-DX-AB2E	SARC	TCGA	SSSLNHVPDL	DEG_COP1_1	0.1667
p.P207S	DO220073	SARC	ICGC	SSSLNHVPDL	DEG_COP1_1	0.1667
p.S228L	TCGA-EE-A29H	SKCM	TCGA	SSSLNHVPDL	DEG_COP1_1	0.1667
p.S228L	DO37535	SKCM	ICGC	SSSLNHVPDL	DEG_COP1_1	0.1667
p.S214F	TCGA-EE-A2M5	SKCM	TCGA	SSSLNHVPDL	DEG_COP1_1	0.6871
p.S214F	DO222423	MELA	ICGC	SSSLNHVPDL	DEG_COP1_1	0.6871
p.S214F	DO37425	SKCM	ICGC	SSSLNHVPDL	DEG_COP1_1	0.6871
p.G225R	TCGA-GN-A26C	SKCM	TCGA	SSSLNHVPDL	DEG_COP1_1	0.25
p.G225R	DO37782	SKCM	ICGC	SSSLNHVPDL	DEG_COP1_1	0.25
p.P205L	DO48372	BLCA	ICGC	SSSLNHVPDL	DEG_COP1_1	0.1111
p.P226L	DO229050	LICA	ICGC	SSSLNHVPDL	DEG_COP1_1	0.2222
p.H218L	DO50897	LICA	ICGC	SSSLNHVPDL	DEG_COP1_1	0.6202
p.S211F	DO222868	MELA	ICGC	SSSLNHVPDL	DEG_COP1_1	0.2778
p.L222F	DO222880	MELA	ICGC	SSSLNHVPDL	DEG_COP1_1	0.587
p.S211P	SIDM01588	Endometrial Carcinoma	GDSC	SSSLNHVPDL	DEG_COP1_1	0.2778
p.S211P	ACH-000993	Endometrial/Uterine Cancer	CCLE	SSSLNHVPDL	DEG_COP1_1	0.2778
p.A224T	ACH-000967	Colon/Colorectal Cancer	CCLE	SSSLNHVPDL	DEG_COP1_1	0.2778
p.A224T	ACH-001199	Colon/Colorectal Cancer	CCLE	SSSLNHVPDL	DEG_COP1_1	0.2778
p.A224T	SNU-C2B	large_intestine	COSMIC	SSSLNHVPDL	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P57052	Splicing regulator RBM11	DEG_COP1_1	171:180	SSSLNHVPDL	COP1	0.9833	More...
P57052	Splicing regulator RBM11	DEG_COP1_1	213:222	SSSLNHVPDL	COP1	0.9197	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSSLNHVPDL

Degron related mutations and impact score

Drug responses associated with RBM11 mutations

All proteins holding degron of SSSLNHVPDL