DegronMD - P68104(EEF1A1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G260C	TCGA-66-2787	LUSC	TCGA	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.G260C	DO26647	LUSC	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.P263S	TCGA-78-7148	LUAD	TCGA	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.0833
p.P263S	DO26112	LUAD	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.0833
p.D252E	TCGA-A6-5666	COAD	TCGA	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation altering degron motif	0.5647
p.D252E	DO9482	COAD	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation altering degron motif	0.5647
p.R247H	TCGA-AX-A1C9	UCEC	TCGA	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation altering degron motif	0.8244
p.R247H	DO43098	UCEC	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation altering degron motif	0.8244
p.D243G	TCGA-DF-A2KU	UCEC	TCGA	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.25
p.D243G	DO223286	UCEC	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.25
p.G260S	TCGA-EE-A17X	SKCM	TCGA	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.G260S	DO222610	COCA	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.G260S	DO37931	SKCM	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.S291C	TCGA-GU-AATO	BLCA	TCGA	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation blocking phosphorylation signal	0.75
p.S291C	TCGA-XF-AAMF	BLCA	TCGA	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation blocking phosphorylation signal	0.75
p.S291C	DO51930	BLCA	ICGC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation blocking phosphorylation signal	0.75
p.S291C	DO51893	BLCA	ICGC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation blocking phosphorylation signal	0.75
p.I259F	DO229054	LICA	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1944
p.L299F	DO229229	THCA	ICGC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.2778
p.R240S	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.R240S	ACH-000900	Lung Cancer	CCLE	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.R240S	NCI-H23	lung	COSMIC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.D252H	ACH-000512	Myeloma	CCLE	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation altering degron motif	0.6577
p.N293S	COR-L303	lung	COSMIC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation altering degron motif	0.7069

Kaplan plot for EEF1A1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EEF1A1

UniProt ID: P68104

Entrez ID: 1915

Protein name: Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EEF1A1 in