DegronMD

Uniprot ID: P68104

Source protein: Elongation factor 1-alpha 1

Source gene: EEF1A1

Class: DEG_APCC_DBOX_1

Location: 246:254

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8623

ASA_SCORE: 33.7111

COIL: 0.4831

CONS_SCORE: 0.7696

DSS_SCORE: 0.3011

HELIX: 0.1311

FCONS_SCORE: 1.3547

RIG_SCORE: 0.8438

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G260C	TCGA-66-2787	LUSC	TCGA	LRLPLQDVY	DEG_APCC_DBOX_1	0.1667
p.G260C	DO26647	LUSC	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.1667
p.P263S	TCGA-78-7148	LUAD	TCGA	LRLPLQDVY	DEG_APCC_DBOX_1	0.0833
p.P263S	DO26112	LUAD	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.0833
p.D252E	TCGA-A6-5666	COAD	TCGA	LRLPLQDVY	DEG_APCC_DBOX_1	0.5647
p.D252E	DO9482	COAD	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.5647
p.R247H	TCGA-AX-A1C9	UCEC	TCGA	LRLPLQDVY	DEG_APCC_DBOX_1	0.8244
p.R247H	DO43098	UCEC	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.8244
p.D243G	TCGA-DF-A2KU	UCEC	TCGA	LRLPLQDVY	DEG_APCC_DBOX_1	0.25
p.D243G	DO223286	UCEC	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.25
p.G260S	TCGA-EE-A17X	SKCM	TCGA	LRLPLQDVY	DEG_APCC_DBOX_1	0.1667
p.G260S	DO222610	COCA	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.1667
p.G260S	DO37931	SKCM	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.1667
p.I259F	DO229054	LICA	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.1944
p.R240S	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	LRLPLQDVY	DEG_APCC_DBOX_1	0.1667
p.R240S	ACH-000900	Lung Cancer	CCLE	LRLPLQDVY	DEG_APCC_DBOX_1	0.1667
p.R240S	NCI-H23	lung	COSMIC	LRLPLQDVY	DEG_APCC_DBOX_1	0.1667
p.D252H	ACH-000512	Myeloma	CCLE	LRLPLQDVY	DEG_APCC_DBOX_1	0.6577

DegronMD: protein-targeted degradation, mutation and drug response to degrons