DegronMD

Uniprot ID: Q05639

Source protein: Elongation factor 1-alpha 2

Source gene: EEF1A2

Class: DEG_APCC_DBOX_1

Location: 246:254

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8506

ASA_SCORE: 34.6333

COIL: 0.4469

CONS_SCORE: 0.758

DSS_SCORE: 0.3002

HELIX: 0.1244

FCONS_SCORE: 1.3731

RIG_SCORE: 0.8374

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R240C	TCGA-AF-2689	READ	TCGA	LRLPLQDVY	DEG_APCC_DBOX_1	0.1667
p.R240C	TCGA-OL-A5RX	BRCA	TCGA	LRLPLQDVY	DEG_APCC_DBOX_1	0.1667
p.R240C	DO44212	BRCA	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.1667
p.R240C	DO230346	COCA	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.1667
p.R240C	DO50306	ESAD	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.1667
p.R240C	DO233079	GACA	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.1667
p.R240C	DO36822	READ	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.1667
p.R247H	TCGA-AP-A1DV	UCEC	TCGA	LRLPLQDVY	DEG_APCC_DBOX_1	0.8244
p.R247H	DO43186	UCEC	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.8244
p.T261M	TCGA-CV-6933	HNSC	TCGA	LRLPLQDVY	DEG_APCC_DBOX_1	0.5833
p.T261M	DO14164	HNSC	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.5833
p.T261M	DO50777	LICA	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.5833
p.P241H	DO230343	COCA	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.1944
p.K255N	DO50349	ESAD	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.75
p.R240H	DO10858	ESAD	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.1667
p.P238T	DO231824	LINC	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.1111
p.TD242TN	DO222843	MELA	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0
p.I259T	DO229250	THCA	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.1944
p.P249L	DO229542	UTCA	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	0.6471
p.T239M	SIDM01956	Colorectal Carcinoma	GDSC	LRLPLQDVY	DEG_APCC_DBOX_1	0.5833
p.G258V	SIDM01445	Gastric Carcinoma	GDSC	LRLPLQDVY	DEG_APCC_DBOX_1	0.2222
p.P245L	ACH-000987	Skin Cancer	CCLE	LRLPLQDVY	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons