DegronMD - Q05639(EEF1A2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L299Q	TCGA-33-A5GW	LUSC	TCGA	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.2778
p.L299Q	DO219122	LUSC	ICGC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.2778
p.E288D	TCGA-49-6743	LUAD	TCGA	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.2222
p.E288D	DO26092	LUAD	ICGC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.2222
p.S291L	TCGA-50-6592	LUAD	TCGA	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation blocking phosphorylation signal	0.75
p.S291L	DO23742	LUAD	ICGC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation blocking phosphorylation signal	0.75
p.A298S	TCGA-58-8391	LUSC	TCGA	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.3056
p.A298S	DO45440	LUSC	ICGC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.3056
p.D306V	TCGA-AC-A3W5	BRCA	TCGA	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.0833
p.D306V	DO49024	BRCA	ICGC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.0833
p.R240C	TCGA-AF-2689	READ	TCGA	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.R240C	TCGA-OL-A5RX	BRCA	TCGA	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.R240C	DO44212	BRCA	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.R240C	DO230346	COCA	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.R240C	DO50306	ESAD	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.R240C	DO233079	GACA	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.R240C	DO36822	READ	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.R247H	TCGA-AP-A1DV	UCEC	TCGA	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation altering degron motif	0.8244
p.R247H	DO43186	UCEC	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation altering degron motif	0.8244
p.T261M	TCGA-CV-6933	HNSC	TCGA	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation blocking phosphorylation signal	0.5833
p.T261M	DO14164	HNSC	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation blocking phosphorylation signal	0.5833
p.T261M	DO50777	LICA	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation blocking phosphorylation signal	0.5833
p.E301K	TCGA-D9-A149	SKCM	TCGA	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.2222
p.E301K	DO37420	SKCM	ICGC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.2222
p.E297K	TCGA-DJ-A13L	THCA	TCGA	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation altering degron motif	0.7022
p.E297K	TCGA-GC-A3YS	BLCA	TCGA	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation altering degron motif	0.7022
p.E297K	DO850	BLCA	ICGC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation altering degron motif	0.7022
p.E297K	DO219585	THCA	ICGC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation altering degron motif	0.7022
p.L299V	TCGA-G4-6315	COAD	TCGA	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.2778
p.L299V	DO9522	COAD	ICGC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.2778
p.P241H	DO230343	COCA	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1944
p.K255N	DO50349	ESAD	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation blocking ubiquitination signal	0.75
p.R240H	DO10858	ESAD	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.P238T	DO231824	LINC	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1111
p.TD242TN	DO222843	MELA	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0
p.I259T	DO229250	THCA	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1944
p.P249L	DO229542	UTCA	ICGC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation altering degron motif	0.6471
p.T239M	SIDM01956	Colorectal Carcinoma	GDSC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation blocking phosphorylation signal	0.5833
p.L303M	SIDM01197	Colorectal Carcinoma	GDSC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.1667
p.L303M	SNU-C1	large intestine	COSMIC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.1667
p.A302V	SIDM00282	Colorectal Carcinoma	GDSC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.1944
p.A302V	ACH-000998	Colon/Colorectal Cancer	CCLE	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.1944
p.A302V	CW-2	large intestine	COSMIC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.1944
p.A302T	SIDM00534	Colorectal Carcinoma	GDSC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.1944
p.A302T	SIDM00901	Endometrial Carcinoma	GDSC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.1944
p.A302T	ACH-000940	Endometrial/Uterine Cancer	CCLE	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.1944
p.A302T	ACH-000986	Colon/Colorectal Cancer	CCLE	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.1944
p.A302T	AN3-CA	endometrium	COSMIC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.1944
p.A302T	HT-115	large intestine	COSMIC	VEMHHE	LIG_APCC_ABBA_1	292:297	Mutation rewiring degron network	0.1944
p.G258V	SIDM01445	Gastric Carcinoma	GDSC	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.2222
p.P245L	ACH-000987	Skin Cancer	CCLE	LRLPLQDVY	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EEF1A2

UniProt ID: Q05639

Entrez ID: 1917

Protein name: Elongation factor 1-alpha 2 (EF-1-alpha-2) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EEF1A2 in