DegronMD

Uniprot ID: Q05639

Source protein: Elongation factor 1-alpha 2

Source gene: EEF1A2

Class: LIG_APCC_ABBA_1

Location: 292:297

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9241

ASA_SCORE: 75.8833

COIL: 0.3093

CONS_SCORE: 0.6301

DSS_SCORE: 0.3773

HELIX: 0.0018

FCONS_SCORE: 1.0188

RIG_SCORE: 0.8102

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L299Q	TCGA-33-A5GW	LUSC	TCGA	VEMHHE	LIG_APCC_ABBA_1	0.2778
p.L299Q	DO219122	LUSC	ICGC	VEMHHE	LIG_APCC_ABBA_1	0.2778
p.E288D	TCGA-49-6743	LUAD	TCGA	VEMHHE	LIG_APCC_ABBA_1	0.2222
p.E288D	DO26092	LUAD	ICGC	VEMHHE	LIG_APCC_ABBA_1	0.2222
p.S291L	TCGA-50-6592	LUAD	TCGA	VEMHHE	LIG_APCC_ABBA_1	0.75
p.S291L	DO23742	LUAD	ICGC	VEMHHE	LIG_APCC_ABBA_1	0.75
p.A298S	TCGA-58-8391	LUSC	TCGA	VEMHHE	LIG_APCC_ABBA_1	0.3056
p.A298S	DO45440	LUSC	ICGC	VEMHHE	LIG_APCC_ABBA_1	0.3056
p.D306V	TCGA-AC-A3W5	BRCA	TCGA	VEMHHE	LIG_APCC_ABBA_1	0.0833
p.D306V	DO49024	BRCA	ICGC	VEMHHE	LIG_APCC_ABBA_1	0.0833
p.E301K	TCGA-D9-A149	SKCM	TCGA	VEMHHE	LIG_APCC_ABBA_1	0.2222
p.E301K	DO37420	SKCM	ICGC	VEMHHE	LIG_APCC_ABBA_1	0.2222
p.E297K	TCGA-DJ-A13L	THCA	TCGA	VEMHHE	LIG_APCC_ABBA_1	0.7022
p.E297K	TCGA-GC-A3YS	BLCA	TCGA	VEMHHE	LIG_APCC_ABBA_1	0.7022
p.E297K	DO850	BLCA	ICGC	VEMHHE	LIG_APCC_ABBA_1	0.7022
p.E297K	DO219585	THCA	ICGC	VEMHHE	LIG_APCC_ABBA_1	0.7022
p.L299V	TCGA-G4-6315	COAD	TCGA	VEMHHE	LIG_APCC_ABBA_1	0.2778
p.L299V	DO9522	COAD	ICGC	VEMHHE	LIG_APCC_ABBA_1	0.2778
p.L303M	SIDM01197	Colorectal Carcinoma	GDSC	VEMHHE	LIG_APCC_ABBA_1	0.1667
p.L303M	SNU-C1	large_intestine	COSMIC	VEMHHE	LIG_APCC_ABBA_1	0.1667
p.A302V	SIDM00282	Colorectal Carcinoma	GDSC	VEMHHE	LIG_APCC_ABBA_1	0.1944
p.A302V	ACH-000998	Colon/Colorectal Cancer	CCLE	VEMHHE	LIG_APCC_ABBA_1	0.1944
p.A302V	CW-2	large_intestine	COSMIC	VEMHHE	LIG_APCC_ABBA_1	0.1944
p.A302T	SIDM00534	Colorectal Carcinoma	GDSC	VEMHHE	LIG_APCC_ABBA_1	0.1944
p.A302T	SIDM00901	Endometrial Carcinoma	GDSC	VEMHHE	LIG_APCC_ABBA_1	0.1944
p.A302T	ACH-000940	Endometrial/Uterine Cancer	CCLE	VEMHHE	LIG_APCC_ABBA_1	0.1944
p.A302T	ACH-000986	Colon/Colorectal Cancer	CCLE	VEMHHE	LIG_APCC_ABBA_1	0.1944
p.A302T	AN3-CA	endometrium	COSMIC	VEMHHE	LIG_APCC_ABBA_1	0.1944
p.A302T	HT-115	large_intestine	COSMIC	VEMHHE	LIG_APCC_ABBA_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VEMHHE

Degron related mutations and impact score

Drug responses associated with EEF1A2 mutations

All proteins holding degron of VEMHHE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P68104	Elongation factor 1-alpha 1	LIG_APCC_ABBA_1	292:297	VEMHHE	APC,CDC20,FZR1	0.8762	More...
Q05639	Elongation factor 1-alpha 2	LIG_APCC_ABBA_1	292:297	VEMHHE	APC,CDC20,FZR1	0.9241	More...
Q5VTE0	Putative elongation factor 1-alpha-like 3	LIG_APCC_ABBA_1	292:297	VEMHHE	APC,CDC20,FZR1	0.7502	More...