DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
VEMHHE
Uniprot ID:
Q5VTE0
Source protein:
Putative elongation factor 1-alpha-like 3
Source gene:
EEF1A1P5
Class:
LIG_APCC_ABBA_1
Location:
292:297
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7502
ASA_SCORE:
70.05
COIL:
0.2678
CONS_SCORE:
0.6402
DSS_SCORE:
0.3994
HELIX:
0.0032
FCONS_SCORE:
1.0154
RIG_SCORE:
0.8153
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with EEF1A1P5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VEMHHE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P68104
Elongation factor 1-alpha 1
LIG_APCC_ABBA_1
292:297
VEMHHE
APC,CDC20,FZR1
0.8762
More...
Q05639
Elongation factor 1-alpha 2
LIG_APCC_ABBA_1
292:297
VEMHHE
APC,CDC20,FZR1
0.9241
More...
Q5VTE0
Putative elongation factor 1-alpha-like 3
LIG_APCC_ABBA_1
292:297
VEMHHE
APC,CDC20,FZR1
0.7502
More...