DegronMD

Uniprot ID: P68104

Source protein: Elongation factor 1-alpha 1

Source gene: EEF1A1

Class: LIG_APCC_ABBA_1

Location: 292:297

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8762

ASA_SCORE: 71.05

COIL: 0.3075

CONS_SCORE: 0.6349

DSS_SCORE: 0.4068

HELIX: 0.0025

FCONS_SCORE: 1.0229

RIG_SCORE: 0.8137

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S291C	TCGA-GU-AATO	BLCA	TCGA	VEMHHE	LIG_APCC_ABBA_1	0.75
p.S291C	TCGA-XF-AAMF	BLCA	TCGA	VEMHHE	LIG_APCC_ABBA_1	0.75
p.S291C	DO51930	BLCA	ICGC	VEMHHE	LIG_APCC_ABBA_1	0.75
p.S291C	DO51893	BLCA	ICGC	VEMHHE	LIG_APCC_ABBA_1	0.75
p.L299F	DO229229	THCA	ICGC	VEMHHE	LIG_APCC_ABBA_1	0.2778
p.N293S	COR-L303	lung	COSMIC	VEMHHE	LIG_APCC_ABBA_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P68104	Elongation factor 1-alpha 1	LIG_APCC_ABBA_1	292:297	VEMHHE	APC,CDC20,FZR1	0.8762	More...
Q05639	Elongation factor 1-alpha 2	LIG_APCC_ABBA_1	292:297	VEMHHE	APC,CDC20,FZR1	0.9241	More...
Q5VTE0	Putative elongation factor 1-alpha-like 3	LIG_APCC_ABBA_1	292:297	VEMHHE	APC,CDC20,FZR1	0.7502	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons