DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VEMHHE
Uniprot ID:
P68104
Source protein:
Elongation factor 1-alpha 1
Source gene:
EEF1A1
Class:
LIG_APCC_ABBA_1
Location:
292:297
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8762
ASA_SCORE:
71.05
COIL:
0.3075
CONS_SCORE:
0.6349
DSS_SCORE:
0.4068
HELIX:
0.0025
FCONS_SCORE:
1.0229
RIG_SCORE:
0.8137
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S291C
TCGA-GU-AATO
BLCA
TCGA
VEMHHE
LIG_APCC_ABBA_1
0.75
p.S291C
TCGA-XF-AAMF
BLCA
TCGA
VEMHHE
LIG_APCC_ABBA_1
0.75
p.S291C
DO51930
BLCA
ICGC
VEMHHE
LIG_APCC_ABBA_1
0.75
p.S291C
DO51893
BLCA
ICGC
VEMHHE
LIG_APCC_ABBA_1
0.75
p.N293S
COR-L303
lung
COSMIC
VEMHHE
LIG_APCC_ABBA_1
0.7069
p.L299F
DO229229
THCA
ICGC
VEMHHE
LIG_APCC_ABBA_1
0.2778
Showing 1 to 6 of 6 entries
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Drug responses associated with EEF1A1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of VEMHHE
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P68104
Elongation factor 1-alpha 1
LIG_APCC_ABBA_1
292:297
VEMHHE
APC,CDC20,FZR1
0.8762
More...
Q05639
Elongation factor 1-alpha 2
LIG_APCC_ABBA_1
292:297
VEMHHE
APC,CDC20,FZR1
0.9241
More...
Q5VTE0
Putative elongation factor 1-alpha-like 3
LIG_APCC_ABBA_1
292:297
VEMHHE
APC,CDC20,FZR1
0.7502
More...
Showing 1 to 3 of 3 entries
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