DegronMD - Q05586(GRIN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G289W	TCGA-05-4417	LUAD	TCGA	EKENI	DEG_APCC_KENBOX_2	297:301	Mutation rewiring degron network	0.1111
p.D304N	TCGA-DK-A3IT	BLCA	TCGA	EKENI	DEG_APCC_KENBOX_2	297:301	Mutation rewiring degron network	0.25
p.D304N	SIDM01004	Chronic Myelogenous Leukemia	GDSC	EKENI	DEG_APCC_KENBOX_2	297:301	Mutation rewiring degron network	0.25
p.D304N	ACH-000983	Leukemia	CCLE	EKENI	DEG_APCC_KENBOX_2	297:301	Mutation rewiring degron network	0.25
p.D304N	KCL-22	haematopoietic and lymphoid tissue	COSMIC	EKENI	DEG_APCC_KENBOX_2	297:301	Mutation rewiring degron network	0.25
p.R880Q	TCGA-EE-A3JI	SKCM	TCGA	AITST	DEG_SPOP_SBC_1	882:886	Mutation rewiring degron network	0.2778
p.K296N	TCGA-F5-6814	READ	TCGA	EKENI	DEG_APCC_KENBOX_2	297:301	Mutation rewiring degron network	0.3056
p.E294K	DO48404	BLCA	ICGC	EKENI	DEG_APCC_KENBOX_2	297:301	Mutation rewiring degron network	0.25
p.E297Q	DO481	BLCA	ICGC	EKENI	DEG_APCC_KENBOX_2	297:301	Mutation altering degron motif	0.5633
p.E297Q	DO45441	LUSC	ICGC	EKENI	DEG_APCC_KENBOX_2	297:301	Mutation altering degron motif	0.5633
p.D890N	DO514	BLCA	ICGC	AITST	DEG_SPOP_SBC_1	882:886	Mutation blocking phosphorylation signal	0.6667
p.R877W	DO645	BLCA	ICGC	AITST	DEG_SPOP_SBC_1	882:886	Mutation substituting flanking lysine	0.3056
p.P305L	DO10582	COAD	ICGC	EKENI	DEG_APCC_KENBOX_2	297:301	Mutation rewiring degron network	0.2222
p.L872R	DO9698	COAD	ICGC	AITST	DEG_SPOP_SBC_1	882:886	Mutation rewiring degron network	0.0556
p.Y886C	DO219841	LGG	ICGC	AITST	DEG_SPOP_SBC_1	882:886	Mutation altering degron motif	0.7087
p.A291S	DO229009	LICA	ICGC	EKENI	DEG_APCC_KENBOX_2	297:301	Mutation rewiring degron network	0.1667
p.A876T	DO44879	LIHC	ICGC	AITST	DEG_SPOP_SBC_1	882:886	Mutation substituting flanking lysine	0.2778
p.G893V	DO219184	LUSC	ICGC	AITST	DEG_SPOP_SBC_1	882:886	Mutation rewiring degron network	0.1389
p.V896L	DO28119	OV	ICGC	AITST	DEG_SPOP_SBC_1	882:886	Mutation blocking phosphorylation signal	0.5
p.H293L	DO219265	PRAD	ICGC	EKENI	DEG_APCC_KENBOX_2	297:301	Mutation rewiring degron network	0.2222
p.G881S	DO37567	SKCM	ICGC	AITST	DEG_SPOP_SBC_1	882:886	Mutation rewiring degron network	0.3056
p.R895M	DO48009	STAD	ICGC	AITST	DEG_SPOP_SBC_1	882:886	Mutation rewiring degron network	0.0833
p.V876I	SIDM02013	Colorectal Carcinoma	GDSC	AITST	DEG_SPOP_SBC_1	882:886	Mutation substituting flanking lysine	0.2778
p.A305V	SIDM00537	Colorectal Carcinoma	GDSC	EKENI	DEG_APCC_KENBOX_2	297:301	Mutation rewiring degron network	0.2222
p.A305V	ACH-000982	Colon/Colorectal Cancer	CCLE	EKENI	DEG_APCC_KENBOX_2	297:301	Mutation rewiring degron network	0.2222
p.A305V	ACH-001345	Colon/Colorectal Cancer	CCLE	EKENI	DEG_APCC_KENBOX_2	297:301	Mutation rewiring degron network	0.2222
p.A305V	GP5d	large intestine	COSMIC	EKENI	DEG_APCC_KENBOX_2	297:301	Mutation rewiring degron network	0.2222
p.V306M	SIDM01608	Endometrial Carcinoma	GDSC	EKENI	DEG_APCC_KENBOX_2	297:301	Mutation rewiring degron network	0.1944
p.V306M	ACH-000990	Endometrial/Uterine Cancer	CCLE	EKENI	DEG_APCC_KENBOX_2	297:301	Mutation rewiring degron network	0.1944
p.T302A	ACH-000971	Colon/Colorectal Cancer	CCLE	EKENI	DEG_APCC_KENBOX_2	297:301	Mutation rewiring degron network	0.3056
p.R894H	SNU-C2B	large intestine	COSMIC	AITST	DEG_SPOP_SBC_1	882:886	Mutation rewiring degron network	0.1111
p.A882P	NALM-6	haematopoietic and lymphoid tissue	COSMIC	AITST	DEG_SPOP_SBC_1	882:886	Mutation altering degron motif	0.6392

Kaplan plot for GRIN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GRIN1

UniProt ID: Q05586

Entrez ID: 2902

Protein name: Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GRIN1 in