DegronMD

Uniprot ID: Q05586

Source protein: Glutamate receptor ionotropic, NMDA 1

Source gene: GRIN1

Class: DEG_APCC_KENBOX_2

Location: 297:301

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7177

ASA_SCORE: 95.78

COIL: 0.6644

CONS_SCORE: 0.3767

DSS_SCORE: 0.3698

HELIX: 0.3224

FCONS_SCORE: 1.0755

RIG_SCORE: 0.7916

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G289W	TCGA-05-4417	LUAD	TCGA	EKENI	DEG_APCC_KENBOX_2	0.1111
p.D304N	TCGA-DK-A3IT	BLCA	TCGA	EKENI	DEG_APCC_KENBOX_2	0.25
p.D304N	SIDM01004	Chronic Myelogenous Leukemia	GDSC	EKENI	DEG_APCC_KENBOX_2	0.25
p.D304N	ACH-000983	Leukemia	CCLE	EKENI	DEG_APCC_KENBOX_2	0.25
p.D304N	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	EKENI	DEG_APCC_KENBOX_2	0.25
p.K296N	TCGA-F5-6814	READ	TCGA	EKENI	DEG_APCC_KENBOX_2	0.3056
p.E294K	DO48404	BLCA	ICGC	EKENI	DEG_APCC_KENBOX_2	0.25
p.E297Q	DO481	BLCA	ICGC	EKENI	DEG_APCC_KENBOX_2	0.5633
p.E297Q	DO45441	LUSC	ICGC	EKENI	DEG_APCC_KENBOX_2	0.5633
p.P305L	DO10582	COAD	ICGC	EKENI	DEG_APCC_KENBOX_2	0.2222
p.A291S	DO229009	LICA	ICGC	EKENI	DEG_APCC_KENBOX_2	0.1667
p.H293L	DO219265	PRAD	ICGC	EKENI	DEG_APCC_KENBOX_2	0.2222
p.A305V	SIDM00537	Colorectal Carcinoma	GDSC	EKENI	DEG_APCC_KENBOX_2	0.2222
p.A305V	ACH-000982	Colon/Colorectal Cancer	CCLE	EKENI	DEG_APCC_KENBOX_2	0.2222
p.A305V	ACH-001345	Colon/Colorectal Cancer	CCLE	EKENI	DEG_APCC_KENBOX_2	0.2222
p.A305V	GP5d	large_intestine	COSMIC	EKENI	DEG_APCC_KENBOX_2	0.2222
p.V306M	SIDM01608	Endometrial Carcinoma	GDSC	EKENI	DEG_APCC_KENBOX_2	0.1944
p.V306M	ACH-000990	Endometrial/Uterine Cancer	CCLE	EKENI	DEG_APCC_KENBOX_2	0.1944
p.T302A	ACH-000971	Colon/Colorectal Cancer	CCLE	EKENI	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78362	SRSF protein kinase 2	DEG_APCC_KENBOX_2	355:359	EKENI	APC,CDC20,FZR1	0.7328	More...
Q05586	Glutamate receptor ionotropic, NMDA 1	DEG_APCC_KENBOX_2	297:301	EKENI	APC,CDC20,FZR1	0.7177	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons