DegronMD

Uniprot ID: P78362

Source protein: SRSF protein kinase 2

Source gene: SRPK2

Class: DEG_APCC_KENBOX_2

Location: 355:359

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7328

ASA_SCORE: 117.66

COIL: 0.3884

CONS_SCORE: 0.2825

DSS_SCORE: 0.8235

HELIX: 0.5846

FCONS_SCORE: 0.9998

RIG_SCORE: 0.6675

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A365V	TCGA-B5-A1MX	UCEC	TCGA	EKENI	DEG_APCC_KENBOX_2	0.1667
p.Q359R	TCGA-VQ-A91K	STAD	TCGA	EKENI	DEG_APCC_KENBOX_2	0.7329
p.E363K	DO219036	BLCA	ICGC	EKENI	DEG_APCC_KENBOX_2	0.2222
p.E360K	DO514	BLCA	ICGC	EKENI	DEG_APCC_KENBOX_2	0.3056
p.E360K	DO38205	STAD	ICGC	EKENI	DEG_APCC_KENBOX_2	0.3056
p.Q348R	DO51785	STAD	ICGC	EKENI	DEG_APCC_KENBOX_2	0.1389
p.A354V	DO41999	UCEC	ICGC	EKENI	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78362	SRSF protein kinase 2	DEG_APCC_KENBOX_2	355:359	EKENI	APC,CDC20,FZR1	0.7328	More...
Q05586	Glutamate receptor ionotropic, NMDA 1	DEG_APCC_KENBOX_2	297:301	EKENI	APC,CDC20,FZR1	0.7177	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons