DegronMD

Uniprot ID: Q05586

Source protein: Glutamate receptor ionotropic, NMDA 1

Source gene: GRIN1

Class: DEG_SPOP_SBC_1

Location: 882:886

E3 ligase: SPOP

DEGRON score: 0.8412

ASA_SCORE: 80.42

COIL: 0.5022

CONS_SCORE: 0.3048

DSS_SCORE: 0.558

HELIX: 0.473

FCONS_SCORE: 0.9197

RIG_SCORE: 0.7763

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R880Q	TCGA-EE-A3JI	SKCM	TCGA	AITST	DEG_SPOP_SBC_1	0.2778
p.D890N	DO514	BLCA	ICGC	AITST	DEG_SPOP_SBC_1	0.6667
p.R877W	DO645	BLCA	ICGC	AITST	DEG_SPOP_SBC_1	0.3056
p.L872R	DO9698	COAD	ICGC	AITST	DEG_SPOP_SBC_1	0.0556
p.Y886C	DO219841	LGG	ICGC	AITST	DEG_SPOP_SBC_1	0.7087
p.A876T	DO44879	LIHC	ICGC	AITST	DEG_SPOP_SBC_1	0.2778
p.G893V	DO219184	LUSC	ICGC	AITST	DEG_SPOP_SBC_1	0.1389
p.V896L	DO28119	OV	ICGC	AITST	DEG_SPOP_SBC_1	0.5
p.G881S	DO37567	SKCM	ICGC	AITST	DEG_SPOP_SBC_1	0.3056
p.R895M	DO48009	STAD	ICGC	AITST	DEG_SPOP_SBC_1	0.0833
p.V876I	SIDM02013	Colorectal Carcinoma	GDSC	AITST	DEG_SPOP_SBC_1	0.2778
p.R894H	SNU-C2B	large_intestine	COSMIC	AITST	DEG_SPOP_SBC_1	0.1111
p.A882P	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	AITST	DEG_SPOP_SBC_1	0.6392

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1685:1689	AITST	SPOP	0.8556	More...
Q05586	Glutamate receptor ionotropic, NMDA 1	DEG_SPOP_SBC_1	882:886	AITST	SPOP	0.8412	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1963:1967	AITST	SPOP	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons