DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
AITST
Uniprot ID:
Q02505
Source protein:
Mucin-3A
Source gene:
MUC3A
Class:
DEG_SPOP_SBC_1
Location:
1685:1689
E3 ligase:
SPOP
DEGRON score:
0.8556
ASA_SCORE:
86.12
COIL:
0.8344
CONS_SCORE:
0.4534
DSS_SCORE:
0.6177
HELIX:
0.0224
FCONS_SCORE:
1
RIG_SCORE:
0.6637
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MUC3A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AITST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q02505
Mucin-3A
DEG_SPOP_SBC_1
1685:1689
AITST
SPOP
0.8556
More...
Q05586
Glutamate receptor ionotropic, NMDA 1
DEG_SPOP_SBC_1
882:886
AITST
SPOP
0.8412
More...
Q8IZF6
Adhesion G-protein coupled receptor G4
DEG_SPOP_SBC_1
1963:1967
AITST
SPOP
0.998
More...