DegronMD - Q5SV97(PERM1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P307L	SIDM01090	Colorectal Carcinoma	GDSC	VSTPASE	DEG_SCF_FBW7_2	300:306	Mutation rewiring degron network	0.3056
p.P307L	SIDM01090	Colorectal Carcinoma	GDSC	VSTPASE	DEG_SCF_FBW7_2	315:321	Mutation rewiring degron network	0.1111
p.P307L	SIDM00087	Plasma Cell Myeloma	GDSC	VSTPASE	DEG_SCF_FBW7_2	300:306	Mutation rewiring degron network	0.3056
p.P307L	SIDM00087	Plasma Cell Myeloma	GDSC	VSTPASE	DEG_SCF_FBW7_2	315:321	Mutation rewiring degron network	0.1111
p.P307L	SIDM00721	Small Cell Lung Carcinoma	GDSC	VSTPASE	DEG_SCF_FBW7_2	300:306	Mutation rewiring degron network	0.3056
p.P307L	SIDM00721	Small Cell Lung Carcinoma	GDSC	VSTPASE	DEG_SCF_FBW7_2	315:321	Mutation rewiring degron network	0.1111
p.P307L	SIDM00257	Neuroblastoma	GDSC	VSTPASE	DEG_SCF_FBW7_2	300:306	Mutation rewiring degron network	0.3056
p.P307L	SIDM00257	Neuroblastoma	GDSC	VSTPASE	DEG_SCF_FBW7_2	315:321	Mutation rewiring degron network	0.1111
p.M328T	SIDM00496	Thyroid Gland Carcinoma	GDSC	VSTPASE	DEG_SCF_FBW7_2	315:321	Mutation rewiring degron network	0.1389
p.M328T	SIDM00496	Thyroid Gland Carcinoma	GDSC	VSTPASE	DEG_SCF_FBW7_2	330:336	Mutation rewiring degron network	0.2778
p.M328T	HTC-C3	thyroid	COSMIC	VSTPASE	DEG_SCF_FBW7_2	315:321	Mutation rewiring degron network	0.1389
p.M328T	HTC-C3	thyroid	COSMIC	VSTPASE	DEG_SCF_FBW7_2	330:336	Mutation rewiring degron network	0.2778
p.D342E	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	VSTPASE	DEG_SCF_FBW7_2	330:336	Mutation rewiring degron network	0.1667
p.D342E	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	VSTPASE	DEG_SCF_FBW7_2	345:351	Mutation rewiring degron network	0.25
p.D325N	SIDM00217	Colorectal Carcinoma	GDSC	VSTPASE	DEG_SCF_FBW7_2	315:321	Mutation rewiring degron network	0.2222
p.D325N	SIDM00217	Colorectal Carcinoma	GDSC	VSTPASE	DEG_SCF_FBW7_2	330:336	Mutation rewiring degron network	0.1944
p.D325N	SNU-1040	large intestine	COSMIC	VSTPASE	DEG_SCF_FBW7_2	315:321	Mutation rewiring degron network	0.2222
p.D325N	SNU-1040	large intestine	COSMIC	VSTPASE	DEG_SCF_FBW7_2	330:336	Mutation rewiring degron network	0.1944
p.R356T	JiyoyeP-2003	haematopoietic and lymphoid tissue	COSMIC	VSTPASE	DEG_SCF_FBW7_2	345:351	Mutation rewiring degron network	0.1944

Kaplan plot for PERM1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PERM1

UniProt ID: Q5SV97

Entrez ID: 84808

Protein name: PGC-1 and ERR-induced regulator in muscle protein 1 (PPARGC1 and ESRR-induced regulator in muscle 1) (Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PERM1 in