DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
VSTPASE
Uniprot ID:
Q5SV97
Source protein:
PGC-1 and ERR-induced regulator in muscle protein 1
Source gene:
PERM1
Class:
DEG_SCF_FBW7_2
Location:
300:306
E3 ligase:
FBXW7
DEGRON score:
0.7255
ASA_SCORE:
88.0143
COIL:
0.9577
CONS_SCORE:
0.2371
DSS_SCORE:
0.7271
HELIX:
0.0176
FCONS_SCORE:
0.6274
RIG_SCORE:
0.6112
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P307L
SIDM01090
Colorectal Carcinoma
GDSC
VSTPASE
DEG_SCF_FBW7_2
0.3056
p.P307L
SIDM00087
Plasma Cell Myeloma
GDSC
VSTPASE
DEG_SCF_FBW7_2
0.3056
p.P307L
SIDM00721
Small Cell Lung Carcinoma
GDSC
VSTPASE
DEG_SCF_FBW7_2
0.3056
p.P307L
SIDM00257
Neuroblastoma
GDSC
VSTPASE
DEG_SCF_FBW7_2
0.3056
Drug responses associated with PERM1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VSTPASE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5SV97
PGC-1 and ERR-induced regulator in muscle protein 1
DEG_SCF_FBW7_2
300:306
VSTPASE
FBXW7
0.7255
More...
Q5SV97
PGC-1 and ERR-induced regulator in muscle protein 1
DEG_SCF_FBW7_2
315:321
VSTPASE
FBXW7
0.9907
More...
Q5SV97
PGC-1 and ERR-induced regulator in muscle protein 1
DEG_SCF_FBW7_2
330:336
VSTPASE
FBXW7
0.9907
More...
Q5SV97
PGC-1 and ERR-induced regulator in muscle protein 1
DEG_SCF_FBW7_2
345:351
VSTPASE
FBXW7
0.9907
More...
Q5SV97
PGC-1 and ERR-induced regulator in muscle protein 1
DEG_SCF_FBW7_2
373:379
VSTPASE
FBXW7
0.7956
More...