DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
VSTPASE
Uniprot ID:
Q5SV97
Source protein:
PGC-1 and ERR-induced regulator in muscle protein 1
Source gene:
PERM1
Class:
DEG_SCF_FBW7_2
Location:
373:379
E3 ligase:
FBXW7
DEGRON score:
0.7956
ASA_SCORE:
87.4714
COIL:
0.9564
CONS_SCORE:
0.4698
DSS_SCORE:
0.686
HELIX:
0.017
FCONS_SCORE:
0.983
RIG_SCORE:
0.5995
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PERM1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VSTPASE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5SV97
PGC-1 and ERR-induced regulator in muscle protein 1
DEG_SCF_FBW7_2
300:306
VSTPASE
FBXW7
0.7255
More...
Q5SV97
PGC-1 and ERR-induced regulator in muscle protein 1
DEG_SCF_FBW7_2
315:321
VSTPASE
FBXW7
0.9907
More...
Q5SV97
PGC-1 and ERR-induced regulator in muscle protein 1
DEG_SCF_FBW7_2
330:336
VSTPASE
FBXW7
0.9907
More...
Q5SV97
PGC-1 and ERR-induced regulator in muscle protein 1
DEG_SCF_FBW7_2
345:351
VSTPASE
FBXW7
0.9907
More...
Q5SV97
PGC-1 and ERR-induced regulator in muscle protein 1
DEG_SCF_FBW7_2
373:379
VSTPASE
FBXW7
0.7956
More...