DegronMD

Uniprot ID: Q5SV97

Source protein: PGC-1 and ERR-induced regulator in muscle protein 1

Source gene: PERM1

Class: DEG_SCF_FBW7_2

Location: 315:321

E3 ligase: FBXW7

DEGRON score: 0.9907

ASA_SCORE: 84.8571

COIL: 0.9457

CONS_SCORE: 0.6238

DSS_SCORE: 0.8554

HELIX: 0.0259

FCONS_SCORE: 1.4686

RIG_SCORE: 0.5746

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P307L	SIDM01090	Colorectal Carcinoma	GDSC	VSTPASE	DEG_SCF_FBW7_2	0.1111
p.P307L	SIDM00087	Plasma Cell Myeloma	GDSC	VSTPASE	DEG_SCF_FBW7_2	0.1111
p.P307L	SIDM00721	Small Cell Lung Carcinoma	GDSC	VSTPASE	DEG_SCF_FBW7_2	0.1111
p.P307L	SIDM00257	Neuroblastoma	GDSC	VSTPASE	DEG_SCF_FBW7_2	0.1111
p.M328T	SIDM00496	Thyroid Gland Carcinoma	GDSC	VSTPASE	DEG_SCF_FBW7_2	0.1389
p.M328T	HTC-C3	thyroid	COSMIC	VSTPASE	DEG_SCF_FBW7_2	0.1389
p.D325N	SIDM00217	Colorectal Carcinoma	GDSC	VSTPASE	DEG_SCF_FBW7_2	0.2222
p.D325N	SNU-1040	large_intestine	COSMIC	VSTPASE	DEG_SCF_FBW7_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SV97	PGC-1 and ERR-induced regulator in muscle protein 1	DEG_SCF_FBW7_2	300:306	VSTPASE	FBXW7	0.7255	More...
Q5SV97	PGC-1 and ERR-induced regulator in muscle protein 1	DEG_SCF_FBW7_2	315:321	VSTPASE	FBXW7	0.9907	More...
Q5SV97	PGC-1 and ERR-induced regulator in muscle protein 1	DEG_SCF_FBW7_2	330:336	VSTPASE	FBXW7	0.9907	More...
Q5SV97	PGC-1 and ERR-induced regulator in muscle protein 1	DEG_SCF_FBW7_2	345:351	VSTPASE	FBXW7	0.9907	More...
Q5SV97	PGC-1 and ERR-induced regulator in muscle protein 1	DEG_SCF_FBW7_2	373:379	VSTPASE	FBXW7	0.7956	More...