DegronMD - Q86VQ3(TXNDC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E281K	TCGA-3N-A9WD	SKCM	TCGA	IPKASVKPS	DEG_SIAH_1	269:277	Mutation rewiring degron network	0.2222
p.E281K	DO222810	MELA	ICGC	IPKASVKPS	DEG_SIAH_1	269:277	Mutation rewiring degron network	0.2222
p.E281K	DO51235	SKCM	ICGC	IPKASVKPS	DEG_SIAH_1	269:277	Mutation rewiring degron network	0.2222
p.P264T	TCGA-55-7994	LUAD	TCGA	IPKASVKPS	DEG_SIAH_1	269:277	Mutation rewiring degron network	0.1944
p.P264T	DO45311	LUAD	ICGC	IPKASVKPS	DEG_SIAH_1	269:277	Mutation rewiring degron network	0.1944
p.G282V	TCGA-90-7769	LUSC	TCGA	IPKASVKPS	DEG_SIAH_1	269:277	Mutation rewiring degron network	0.1944
p.G282V	DO26822	LUSC	ICGC	IPKASVKPS	DEG_SIAH_1	269:277	Mutation rewiring degron network	0.1944
p.P279T	TCGA-CN-A63W	HNSC	TCGA	IPKASVKPS	DEG_SIAH_1	269:277	Mutation rewiring degron network	0.2778
p.P279T	DO49031	HNSC	ICGC	IPKASVKPS	DEG_SIAH_1	269:277	Mutation rewiring degron network	0.2778
p.G162D	TCGA-DU-A5TU	LGG	TCGA	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.2778
p.G162D	DO44579	LGG	ICGC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.2778
p.P180S	TCGA-FS-A1YW	SKCM	TCGA	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.1111
p.P180S	DO229341	BTCA	ICGC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.1111
p.P180S	DO227489	LAML	ICGC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.1111
p.P180S	DO228659	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.1111
p.P180S	DO50815	LIRI	ICGC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.1111
p.P180S	DO37734	SKCM	ICGC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.1111
p.I157T	TCGA-MI-A75I	LIHC	TCGA	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.1389
p.I157T	DO49712	LIHC	ICGC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.1389
p.P270A	DO225358	BRCA	ICGC	IPKASVKPS	DEG_SIAH_1	269:277	Mutation altering degron motif	0.7503
p.A167T	DO228580	GACA	ICGC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation altering degron motif	0.7139
p.A167T	DO227513	LAML	ICGC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation altering degron motif	0.7139
p.A167T	DO228937	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation altering degron motif	0.7139
p.A167T	DO228269	MALY	ICGC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation altering degron motif	0.7139
p.A182S	DO227496	LAML	ICGC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.0556
p.A182S	DO228937	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.0556
p.A182S	DO229038	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.0556
p.P165A	DO227513	LAML	ICGC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation altering degron motif	0.7503
p.P165A	DO228915	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation altering degron motif	0.7503
p.P165A	DO228918	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation altering degron motif	0.7503
p.P165A	DO228917	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation altering degron motif	0.7503
p.S285P	DO228925	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	269:277	Mutation rewiring degron network	0.1111
p.S285P	DO229044	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	269:277	Mutation rewiring degron network	0.1111
p.A272T	DO228934	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	269:277	Mutation altering degron motif	0.7139
p.A272T	DO230554	LUSC	ICGC	IPKASVKPS	DEG_SIAH_1	269:277	Mutation altering degron motif	0.7139
p.G282C	DO229028	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	269:277	Mutation rewiring degron network	0.1944
p.A272S	DO229041	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	269:277	Mutation altering degron motif	0.7588
p.I262V	DO229006	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	269:277	Mutation rewiring degron network	0.1389
p.G177S	DO224621	LUSC	ICGC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.1944
p.P171L	DO52365	LUSC	ICGC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation altering degron motif	0.7582
p.I262L	DO220903	MELA	ICGC	IPKASVKPS	DEG_SIAH_1	269:277	Mutation rewiring degron network	0.1389
p.K275R	SIDM01004	Chronic Myelogenous Leukemia	GDSC	IPKASVKPS	DEG_SIAH_1	269:277	Mutation altering degron motif	0.6126
p.G282D	SIDM00480	Ovarian Carcinoma	GDSC	IPKASVKPS	DEG_SIAH_1	269:277	Mutation rewiring degron network	0.1944
p.G282D	OAW-42	ovary	COSMIC	IPKASVKPS	DEG_SIAH_1	269:277	Mutation rewiring degron network	0.1944
p.P174L	SIDM01242	Melanoma	GDSC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.2778
p.P174L	ACH-002084	Skin Cancer	CCLE	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.2778
p.P174L	ACH-002162	Skin Cancer	CCLE	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.2778
p.P174L	MMAC-SF	skin	COSMIC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.2778
p.P174S	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.2778
p.P174S	ACH-000843	Lung Cancer	CCLE	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.2778
p.P174S	HARA	lung	COSMIC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.2778
p.P159H	SIDM01653	Non-Cancerous	GDSC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.1944
p.P159H	SIDM01019	Acute Myeloid Leukemia	GDSC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.1944
p.P159H	SIDM00970	Bladder Carcinoma	GDSC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.1944
p.P159H	SIDM00207	Glioblastoma	GDSC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.1944
p.P159H	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	IPKASVKPS	DEG_SIAH_1	164:172	Mutation rewiring degron network	0.1944
p.P276S	SIDM01561	Melanoma	GDSC	IPKASVKPS	DEG_SIAH_1	269:277	Mutation altering degron motif	0.6752
p.P276S	ACH-000799	Skin Cancer	CCLE	IPKASVKPS	DEG_SIAH_1	269:277	Mutation altering degron motif	0.6752
p.P261A	ACH-000949	Gastric Cancer	CCLE	IPKASVKPS	DEG_SIAH_1	269:277	Mutation rewiring degron network	0.1111
p.P261A	TGBC11TKB	stomach	COSMIC	IPKASVKPS	DEG_SIAH_1	269:277	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TXNDC2

UniProt ID: Q86VQ3

Entrez ID: 84203

Protein name: Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TXNDC2 in