DegronMD

Uniprot ID: Q86VQ3

Source protein: Thioredoxin domain-containing protein 2

Source gene: TXNDC2

Class: DEG_SIAH_1

Location: 164:172

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9365

ASA_SCORE: 92.7111

COIL: 0.9569

CONS_SCORE: 0.8011

DSS_SCORE: 0.7247

HELIX: 0.0191

FCONS_SCORE: 1.0088

RIG_SCORE: 0.6019

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G162D	TCGA-DU-A5TU	LGG	TCGA	IPKASVKPS	DEG_SIAH_1	0.2778
p.G162D	DO44579	LGG	ICGC	IPKASVKPS	DEG_SIAH_1	0.2778
p.P180S	TCGA-FS-A1YW	SKCM	TCGA	IPKASVKPS	DEG_SIAH_1	0.1111
p.P180S	DO229341	BTCA	ICGC	IPKASVKPS	DEG_SIAH_1	0.1111
p.P180S	DO227489	LAML	ICGC	IPKASVKPS	DEG_SIAH_1	0.1111
p.P180S	DO228659	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	0.1111
p.P180S	DO50815	LIRI	ICGC	IPKASVKPS	DEG_SIAH_1	0.1111
p.P180S	DO37734	SKCM	ICGC	IPKASVKPS	DEG_SIAH_1	0.1111
p.I157T	TCGA-MI-A75I	LIHC	TCGA	IPKASVKPS	DEG_SIAH_1	0.1389
p.I157T	DO49712	LIHC	ICGC	IPKASVKPS	DEG_SIAH_1	0.1389
p.A167T	DO228580	GACA	ICGC	IPKASVKPS	DEG_SIAH_1	0.7139
p.A167T	DO227513	LAML	ICGC	IPKASVKPS	DEG_SIAH_1	0.7139
p.A167T	DO228937	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	0.7139
p.A167T	DO228269	MALY	ICGC	IPKASVKPS	DEG_SIAH_1	0.7139
p.A182S	DO227496	LAML	ICGC	IPKASVKPS	DEG_SIAH_1	0.0556
p.A182S	DO228937	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	0.0556
p.A182S	DO229038	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	0.0556
p.P165A	DO227513	LAML	ICGC	IPKASVKPS	DEG_SIAH_1	0.7503
p.P165A	DO228915	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	0.7503
p.P165A	DO228918	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	0.7503
p.P165A	DO228917	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	0.7503
p.G177S	DO224621	LUSC	ICGC	IPKASVKPS	DEG_SIAH_1	0.1944
p.P171L	DO52365	LUSC	ICGC	IPKASVKPS	DEG_SIAH_1	0.7582
p.P174L	SIDM01242	Melanoma	GDSC	IPKASVKPS	DEG_SIAH_1	0.2778
p.P174L	ACH-002084	Skin Cancer	CCLE	IPKASVKPS	DEG_SIAH_1	0.2778
p.P174L	ACH-002162	Skin Cancer	CCLE	IPKASVKPS	DEG_SIAH_1	0.2778
p.P174L	MMAC-SF	skin	COSMIC	IPKASVKPS	DEG_SIAH_1	0.2778
p.P174S	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	IPKASVKPS	DEG_SIAH_1	0.2778
p.P174S	ACH-000843	Lung Cancer	CCLE	IPKASVKPS	DEG_SIAH_1	0.2778
p.P174S	HARA	lung	COSMIC	IPKASVKPS	DEG_SIAH_1	0.2778
p.P159H	SIDM01653	Non-Cancerous	GDSC	IPKASVKPS	DEG_SIAH_1	0.1944
p.P159H	SIDM01019	Acute Myeloid Leukemia	GDSC	IPKASVKPS	DEG_SIAH_1	0.1944
p.P159H	SIDM00970	Bladder Carcinoma	GDSC	IPKASVKPS	DEG_SIAH_1	0.1944
p.P159H	SIDM00207	Glioblastoma	GDSC	IPKASVKPS	DEG_SIAH_1	0.1944
p.P159H	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	IPKASVKPS	DEG_SIAH_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IPKASVKPS

Degron related mutations and impact score

Drug responses associated with TXNDC2 mutations

All proteins holding degron of IPKASVKPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86VQ3	Thioredoxin domain-containing protein 2	DEG_SIAH_1	164:172	IPKASVKPS	SIAH1,SIAH2,SIAH3	0.9365	More...
Q86VQ3	Thioredoxin domain-containing protein 2	DEG_SIAH_1	269:277	IPKASVKPS	SIAH1,SIAH2,SIAH3	0.942	More...