DegronMD

Uniprot ID: Q86VQ3

Source protein: Thioredoxin domain-containing protein 2

Source gene: TXNDC2

Class: DEG_SIAH_1

Location: 269:277

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.942

ASA_SCORE: 91.1556

COIL: 0.9556

CONS_SCORE: 0.8039

DSS_SCORE: 0.7253

HELIX: 0.0198

FCONS_SCORE: 1.0041

RIG_SCORE: 0.6096

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A272S	DO229041	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	0.7588
p.P270A	DO225358	BRCA	ICGC	IPKASVKPS	DEG_SIAH_1	0.7503
p.A272T	DO228934	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	0.7139
p.A272T	DO230554	LUSC	ICGC	IPKASVKPS	DEG_SIAH_1	0.7139
p.P276S	SIDM01561	Melanoma	GDSC	IPKASVKPS	DEG_SIAH_1	0.6752
p.P276S	ACH-000799	Skin Cancer	CCLE	IPKASVKPS	DEG_SIAH_1	0.6752
p.K275R	SIDM01004	Chronic Myelogenous Leukemia	GDSC	IPKASVKPS	DEG_SIAH_1	0.6126
p.P279T	TCGA-CN-A63W	HNSC	TCGA	IPKASVKPS	DEG_SIAH_1	0.2778
p.P279T	DO49031	HNSC	ICGC	IPKASVKPS	DEG_SIAH_1	0.2778
p.E281K	TCGA-3N-A9WD	SKCM	TCGA	IPKASVKPS	DEG_SIAH_1	0.2222
p.E281K	DO222810	MELA	ICGC	IPKASVKPS	DEG_SIAH_1	0.2222
p.E281K	DO51235	SKCM	ICGC	IPKASVKPS	DEG_SIAH_1	0.2222
p.P264T	TCGA-55-7994	LUAD	TCGA	IPKASVKPS	DEG_SIAH_1	0.1944
p.P264T	DO45311	LUAD	ICGC	IPKASVKPS	DEG_SIAH_1	0.1944
p.G282V	TCGA-90-7769	LUSC	TCGA	IPKASVKPS	DEG_SIAH_1	0.1944
p.G282V	DO26822	LUSC	ICGC	IPKASVKPS	DEG_SIAH_1	0.1944
p.G282C	DO229028	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	0.1944
p.G282D	SIDM00480	Ovarian Carcinoma	GDSC	IPKASVKPS	DEG_SIAH_1	0.1944
p.G282D	OAW-42	ovary	COSMIC	IPKASVKPS	DEG_SIAH_1	0.1944
p.I262V	DO229006	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	0.1389
p.I262L	DO220903	MELA	ICGC	IPKASVKPS	DEG_SIAH_1	0.1389
p.S285P	DO228925	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	0.1111
p.S285P	DO229044	LICA	ICGC	IPKASVKPS	DEG_SIAH_1	0.1111
p.P261A	ACH-000949	Gastric Cancer	CCLE	IPKASVKPS	DEG_SIAH_1	0.1111
p.P261A	TGBC11TKB	stomach	COSMIC	IPKASVKPS	DEG_SIAH_1	0.1111

Showing 1 to 25 of 25 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86VQ3	Thioredoxin domain-containing protein 2	DEG_SIAH_1	164:172	IPKASVKPS	SIAH1,SIAH2,SIAH3	0.9365	More...
Q86VQ3	Thioredoxin domain-containing protein 2	DEG_SIAH_1	269:277	IPKASVKPS	SIAH1,SIAH2,SIAH3	0.942	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons