BMPR1B
Entrez ID: 658
Full name: bone morphogenetic protein receptor type 1B
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: STKR: STKR1
Chromosomal location: 4q22.3
Substructure location: Gatekeeper: 279 A-loop: 349...376 G-loop: 211...218 αC-helix: 235...237
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BMPR1B
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5....
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.
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GO - Biological processes (BP):
BMP signaling pathway, cartilage condensation, cellular response to BMP stimulus, cellular response to growth factor stimulus, chondrocyte development, dorsal/ventral pattern formation, endochondral bone morphogenesis, eye development, inflammatory response, limb morphogenesis, negative regulation o...
BMP signaling pathway, cartilage condensation, cellular response to BMP stimulus, cellular response to growth factor stimulus, chondrocyte development, dorsal/ventral pattern formation, endochondral bone morphogenesis, eye development, inflammatory response, limb morphogenesis, negative regulation of chondrocyte proliferation, ovarian cumulus expansion, ovulation cycle, positive regulation of bone mineralization, positive regulation of cartilage development, positive regulation of cell differentiation, positive regulation of chondrocyte differentiation, positive regulation of extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of osteoblast differentiation, positive regulation of transcription by RNA polymerase II, protein phosphorylation, proteoglycan biosynthetic process, retina development in camera-type eye, retinal ganglion cell axon guidance, skeletal system development
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GO - Molecular function (MF):
ATP binding, metal ion binding, protein serine/threonine kinase activity, SMAD binding, transforming growth factor beta receptor activity, type I, transmembrane receptor protein serine/threonine kinase activity...
ATP binding, metal ion binding, protein serine/threonine kinase activity, SMAD binding, transforming growth factor beta receptor activity, type I, transmembrane receptor protein serine/threonine kinase activity
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GO - Cellular component (CC):
HFE-transferrin receptor complex, integral component of plasma membrane, plasma membrane, dendrite, neuronal cell body, receptor complex...
HFE-transferrin receptor complex, integral component of plasma membrane, plasma membrane, dendrite, neuronal cell body, receptor complex
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bone morphogenetic protein receptor type 1B
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Kaplan plot for BMPR1B in
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*NOTE: the Kaplan plots were collected from OncoLnc