Drug resistance
AVG_IC50 (Mutated): the average IC50 value for the drug treatments in cell lines that have mutations in the 4 substurctures.
AVG_IC50 (Non-mutated): the average IC50 value for the drug treatments in cell lines without mutation in the 4 substurctures.
| Kinase | Drug | Cancer code | Cancer type | AVG_IC50(uM)(mutated) | AVG_IC50(uM)(Non-mutated) | Details |
| AKT1 | GSK690693 | UCEC | endometrium | 62.0577 | 24.9933 | More.. |
| AKT1 | MK-2206 | UCEC | endometrium | 235.3745 | 18.4376 | More.. |
| AKT2 | AKT inhibitor VIII | SCLC | lung_small_cell_carcinoma | 28.8596 | 21.1566 | More.. |
| AKT2 | Uprosertib | SCLC | lung_small_cell_carcinoma | 58.2394 | 40.6433 | More.. |
| ALK | Alectinib | DLBC | B_cell_lymphoma | 37.2207 | 29.0609 | More.. |
| ALK | Crizotinib | DLBC | B_cell_lymphoma | 18.5283 | 10.8294 | More.. |
| ALK | XMD14-99 | DLBC | B_cell_lymphoma | 40.6439 | 36.1025 | More.. |
| AURKC | BX795 | UNCLASSIFIED | lung_NSCLC_not_specified | 76.5664 | 13.676 | More.. |
| AURKC | GSK1070916 | KIRC | kidney | 23.1804 | 19.6754 | More.. |
| AURKC | Tozasertib | UNCLASSIFIED | lung_NSCLC_not_specified | 14.8051 | 5.9897 | More.. |
| BMX | QL-XII-47 | LAML | acute_myeloid_leukaemia | 5.7441 | 1.6628 | More.. |
| BMX | WZ-1-84 | LAML | acute_myeloid_leukaemia | 88.0857 | 52.0229 | More.. |
| BRAF | AZ628 | LUAD | lung_NSCLC_adenocarcinoma | 22.0213 | 9.4282 | More.. |
| BRAF | Dabrafenib | COREAD | large_intestine | 199.325 | 192.9775 | More.. |
| BRAF | HG6-64-1 | LUAD | lung_NSCLC_adenocarcinoma | 17.6081 | 16.644 | More.. |
| BRAF | PLX-4720 | BRCA | breast | 191.8173 | 169.2162 | More.. |
| BRAF | PLX-4720 | SKCM | melanoma | 76.3707 | 30.5197 | More.. |
| CDK2 | AZD5438 | COREAD | large_intestine | 155.351 | 24.3599 | More.. |
| CDK2 | MK-8776 | THCA | thyroid | 142.8818 | 64.9446 | More.. |
| CDK6 | AT-7519 | THCA | thyroid | 150.7509 | 22.1516 | More.. |
| CDK6 | Palbociclib | THCA | thyroid | 248.124 | 68.3537 | More.. |
| CDK9 | TL-1-85 | COREAD | large_intestine | 123.9686 | 102.7307 | More.. |
| CSF1R | GW-2580 | ESCA | oesophagus | 306.1414 | 262.7783 | More.. |
| DDR1 | QL-XI-92 | MM | myeloma | 17.0624 | 13.4321 | More.. |
| DDR1 | QL-XI-92 | UNCLASSIFIED | anaplastic_large_cell_lymphoma | 23.6282 | 3.7261 | More.. |
| EGFR | Afatinib | LUAD | lung_NSCLC_adenocarcinoma | 0.9592 | 0.0191 | More.. |
| EGFR | Afatinib | UNCLASSIFIED | Burkitt_lymphoma | 23.7309 | 20.198 | More.. |
| EGFR | AST-1306 | LUAD | lung_NSCLC_adenocarcinoma | 1.1852 | 0.2463 | More.. |
| EGFR | AZD3759 | UNCLASSIFIED | Burkitt_lymphoma | 20.1487 | 11.0618 | More.. |
| EGFR | AZD8931 | LUAD | lung_NSCLC_adenocarcinoma | 2.622 | 0.0531 | More.. |
| EGFR | Cetuximab | LUAD | lung_NSCLC_adenocarcinoma | 69.9293 | 6.8975 | More.. |
| EGFR | Cetuximab | UNCLASSIFIED | Burkitt_lymphoma | 812.9194 | 546.6786 | More.. |
| EGFR | CI-1033 | LUAD | lung_NSCLC_adenocarcinoma | 2.1347 | 0.2929 | More.. |
| EGFR | CUDC-101 | LUAD | lung_NSCLC_adenocarcinoma | 1.3804 | 0.165 | More.. |
| EGFR | Erlotinib | UNCLASSIFIED | Burkitt_lymphoma | 20.2694 | 10.3597 | More.. |
| EGFR | Foretinib | UNCLASSIFIED | Burkitt_lymphoma | 3.3933 | 1.2532 | More.. |
| EGFR | Gefitinib | LUAD | lung_NSCLC_adenocarcinoma | 9.8753 | 0.0121 | More.. |
| EGFR | Gefitinib | UNCLASSIFIED | Burkitt_lymphoma | 15.191 | 9.6238 | More.. |
| EGFR | Lapatinib | UNCLASSIFIED | Burkitt_lymphoma | 13.9917 | 9.9664 | More.. |
| EGFR | Pelitinib | LUAD | lung_NSCLC_adenocarcinoma | 0.0604 | 0.0543 | More.. |
| EGFR | PF-00299804 | COREAD | large_intestine | 24.4517 | 22.331 | More.. |
| EGFR | PF-00299804 | LUAD | lung_NSCLC_adenocarcinoma | 1.6263 | 0.2417 | More.. |
| EGFR | Sapitinib | LUAD | lung_NSCLC_adenocarcinoma | 3.5254 | 0.0979 | More.. |
| EPHA2 | Dasatinib | SCLC | lung_small_cell_carcinoma | 29.5421 | 22.0631 | More.. |
| ERBB4 | AST-1306 | LAML | acute_myeloid_leukaemia | 4.8215 | 4.4793 | More.. |
| ERBB4 | AST-1306 | SKCM | melanoma | 22.8082 | 5.8994 | More.. |
| ERBB4 | AST-1306 | UCEC | endometrium | 13.2253 | 5.5178 | More.. |
| ERBB4 | AST-1306 | UNCLASSIFIED | lung_NSCLC_carcinoid | 6.282 | 5.0641 | More.. |
| ERBB4 | CI-1033 | SKCM | melanoma | 23.8639 | 8.6932 | More.. |
| ERBB4 | CI-1033 | UCEC | endometrium | 8.9198 | 6.6994 | More.. |
| ERBB4 | PF-00299804 | SKCM | melanoma | 24.0428 | 12.7595 | More.. |
| ERBB4 | PF-00299804 | UCEC | endometrium | 17.4219 | 10.298 | More.. |
| FGFR4 | FGFR_0939 | COREAD | large_intestine | 48.7178 | 19.3063 | More.. |
| FLT1 | Cabozantinib | BLCA | bladder | 32.8868 | 30.227 | More.. |
| FLT1 | Cabozantinib | UNCLASSIFIED | ovary | 25.621 | 19.2004 | More.. |
| FLT1 | Cediranib | BLCA | bladder | 147.0583 | 12.3223 | More.. |
| FLT1 | Cediranib | UNCLASSIFIED | anaplastic_large_cell_lymphoma | 5.8298 | 4.1008 | More.. |
| FLT1 | Linifanib | UNCLASSIFIED | ovary | 11.8566 | 9.8702 | More.. |
| FLT1 | Midostaurin | BLCA | bladder | 1.7165 | 1.4931 | More.. |
| FLT1 | Tivozanib | BLCA | bladder | 1.8598 | 1.5754 | More.. |
| FLT1 | Tivozanib | UNCLASSIFIED | ovary | 2.5587 | 1.3064 | More.. |
| FLT3 | Lestaurtinib | LUAD | lung_NSCLC_adenocarcinoma | 6.5216 | 5.5234 | More.. |
| FLT3 | Ponatinib | LUAD | lung_NSCLC_adenocarcinoma | 5.3224 | 4.8343 | More.. |
| FLT3 | Quizartinib | LUAD | lung_NSCLC_adenocarcinoma | 20.1255 | 14.9548 | More.. |
| GSK3B | AZD7969 | ALL | lymphoblastic_leukemia | 3.685 | 3.4326 | More.. |
| GSK3B | KIN001-042 | ALL | lymphoblastic_leukemia | 82.8107 | 73.5215 | More.. |
| GSK3B | SB216763 | ALL | lymphoblastic_leukemia | 39.2571 | 33.733 | More.. |
| IGF1R | BMS-536924 | UNCLASSIFIED | fibrosarcoma | 110.4528 | 13.8492 | More.. |
| IGF1R | BMS-754807 | UNCLASSIFIED | fibrosarcoma | 25.2865 | 1.4107 | More.. |
| IGF1R | GSK1904529A | UNCLASSIFIED | fibrosarcoma | 70.7571 | 27.3638 | More.. |
| IGF1R | Linsitinib | UNCLASSIFIED | fibrosarcoma | 320.6598 | 31.5972 | More.. |
| IGF1R | NVP-ADW742 | UNCLASSIFIED | fibrosarcoma | 369.5607 | 10.9558 | More.. |
| IKBKB | BMS-345541 | STAD | stomach | 27.0304 | 25.3938 | More.. |
| IKBKB | TPCA-1 | STAD | stomach | 103.6547 | 74.2564 | More.. |
| ITK | BMS-509744 | STAD | stomach | 117.3265 | 18.8321 | More.. |
| ITK | Staurosporine | UCEC | endometrium | 0.2205 | 0.1593 | More.. |
| ITK | Staurosporine | UNCLASSIFIED | ewings_sarcoma | 0.0989 | 0.0837 | More.. |
| JAK1 | AZD1480 | UNCLASSIFIED | endometrium | 3.9166 | 0.4414 | More.. |
| JAK1 | JAK1_3715 | UNCLASSIFIED | endometrium | 90.1161 | 48.4274 | More.. |
| JAK1 | JAK1_8709 | GBM | glioma | 162.4954 | 142.9787 | More.. |
| JAK1 | JAK1_8709 | UNCLASSIFIED | endometrium | 67.0713 | 33.19 | More.. |
| JAK1 | JAK_8517 | GBM | glioma | 173.1292 | 56.1354 | More.. |
| JAK1 | JAK_8517 | UNCLASSIFIED | endometrium | 176.2048 | 2.4967 | More.. |
| JAK1 | Ruxolitinib | GBM | glioma | 144.2144 | 120.4131 | More.. |
| JAK1 | Ruxolitinib | UNCLASSIFIED | endometrium | 108.682 | 39.1569 | More.. |
| JAK3 | JAK3_7406 | UCEC | endometrium | 113.8295 | 55.6815 | More.. |
| JAK3 | WHI-P97 | UCEC | endometrium | 98.2843 | 80.5835 | More.. |
| KDR | Linifanib | COREAD | large_intestine | 18.5488 | 16.919 | More.. |
| KDR | Motesanib | COREAD | large_intestine | 41.1438 | 40.1887 | More.. |
| KDR | Motesanib | PRAD | prostate | 30.6555 | 12.079 | More.. |
| KDR | Ponatinib | UNCLASSIFIED | lung_NSCLC_carcinoid | 6.5232 | 5.613 | More.. |
| KDR | Sunitinib | PRAD | prostate | 69.7013 | 34.8929 | More.. |
| KIT | Dasatinib | LAML | acute_myeloid_leukaemia | 12.8718 | 7.8024 | More.. |
| KIT | Imatinib | LAML | acute_myeloid_leukaemia | 23.4979 | 15.9051 | More.. |
| KIT | Sorafenib | LAML | acute_myeloid_leukaemia | 40.2854 | 4.4655 | More.. |
| KIT | Sorafenib | SKCM | melanoma | 29.1322 | 17.0153 | More.. |
| KIT | Sunitinib | LAML | acute_myeloid_leukaemia | 35.55 | 6.7039 | More.. |
| LCK | JW-7-24-1 | ALL | lymphoblastic_leukemia | 1.4246 | 0.6944 | More.. |
| LCK | Staurosporine | ALL | lymphoblastic_leukemia | 0.0532 | 0.0288 | More.. |
| LIMK1 | LIMK1 inhibitor BMS4 | COREAD | large_intestine | 550.073 | 337.792 | More.. |
| LIMK1 | LIMK1 inhibitor BMS4 | LIHC | liver | 311.2393 | 122.3768 | More.. |
| LTK | HG-5-113-01 | PRAD | prostate | 7.8398 | 4.7173 | More.. |
| LTK | XMD14-99 | GBM | glioma | 133.0294 | 131.3875 | More.. |
| LTK | XMD14-99 | UNCLASSIFIED | ewings_sarcoma | 51.1122 | 36.8832 | More.. |
| LTK | XMD14-99 | UNCLASSIFIED | lung_NSCLC_adenocarcinoma | 189.9626 | 161.3321 | More.. |
| MAPK7 | XMD8-92 | UNCLASSIFIED | fibrosarcoma | 50.9333 | 0.1699 | More.. |
| MKNK1 | ETP-45835 | HNSC | head_and_neck | 265.1919 | 153.9431 | More.. |
| NTRK1 | AZD1332 | UNCLASSIFIED | B_cell_leukemia | 58.3567 | 46.1816 | More.. |
| NTRK1 | GW441756 | ALL | lymphoblastic_leukemia | 17.7777 | 17.3997 | More.. |
| NTRK1 | GW441756 | THCA | thyroid | 28.9243 | 15.6639 | More.. |
| NTRK1 | GW441756 | UCEC | endometrium | 16.7441 | 11.9791 | More.. |
| NTRK1 | GW441756 | UNCLASSIFIED | B_cell_leukemia | 38.3105 | 24.7002 | More.. |
| NTRK3 | AZD1332 | ALL | lymphoblastic_T_cell_leukaemia | 37.467 | 20.9519 | More.. |
| NTRK3 | AZD1332 | SCLC | lung_small_cell_carcinoma | 106.1497 | 57.6346 | More.. |
| NTRK3 | AZD1332 | SKCM | melanoma | 223.2007 | 75.0987 | More.. |
| NTRK3 | Lestaurtinib | ALL | lymphoblastic_T_cell_leukaemia | 0.4766 | 0.2518 | More.. |
| PDGFRA | Pazopanib | COREAD | large_intestine | 234.9693 | 98.8435 | More.. |
| PDGFRA | Ponatinib | COREAD | large_intestine | 13.9216 | 5.3747 | More.. |
| PDGFRB | Brivanib, BMS-540215 | PRAD | prostate | 95.9907 | 46.2081 | More.. |
| PDGFRB | Dasatinib | PRAD | prostate | 52.0138 | 10.5922 | More.. |
| PDGFRB | Masitinib | PRAD | prostate | 77.1652 | 76.6198 | More.. |
| PDGFRB | Motesanib | PRAD | prostate | 22.6324 | 13.6836 | More.. |
| PDGFRB | Pazopanib | PRAD | prostate | 50.5275 | 40.7679 | More.. |
| PDGFRB | Sorafenib | PRAD | prostate | 26.2459 | 26.1382 | More.. |
| RET | Cabozantinib | PRAD | prostate | 63.4851 | 12.5383 | More.. |
| ROCK1 | GSK269962A | DLBC | B_cell_lymphoma | 16.623 | 9.1787 | More.. |
| ROCK1 | GSK269962A | PRAD | prostate | 27.7357 | 17.2031 | More.. |
| ROS1 | Crizotinib | GBM | glioma | 560.1637 | 42.8829 | More.. |
| RPS6KA3 | CMK | UNCLASSIFIED | endometrium | 3.0104 | 3.0059 | More.. |
| RPS6KA3 | FMK | LAML | acute_myeloid_leukaemia | 65.9359 | 38.0242 | More.. |
| RPS6KA3 | FMK | OV | ovary | 251.4382 | 194.188 | More.. |
| RPS6KA3 | SL0101 | UNCLASSIFIED | endometrium | 99.257 | 42.9177 | More.. |
| SRPK1 | XMD11-85h | COREAD | large_intestine | 111.2169 | 88.5307 | More.. |
| STK10 | HG-5-113-01 | UNCLASSIFIED | B_cell_leukemia | 5.4219 | 1.4431 | More.. |
| SYK | BAY-61-3606 | KIRC | kidney | 319.3293 | 15.0456 | More.. |
| TGFBR1 | SB505124 | LUAD | lung_NSCLC_adenocarcinoma | 180.4073 | 135.6986 | More.. |
| TGFBR1 | SB52334 | LUAD | lung_NSCLC_adenocarcinoma | 234.8293 | 172.3007 | More.. |