PLK4
Entrez ID: 10733
Full name: polo like kinase 4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: PLK: SAK
Chromosomal location: 4q28.1
Substructure location: Gatekeeper: 89 A-loop: 153...176 G-loop: 18...24 αC-helix: 45...50
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PLK4
Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When ...
Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124).
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GO - Biological processes (BP):
centriole replication, ciliary basal body-plasma membrane docking, de novo centriole assembly involved in multi-ciliated epithelial cell differentiation, G2/M transition of mitotic cell cycle, mitotic cell cycle, positive regulation of centriole replication, protein phosphorylation, regulation of cy...
centriole replication, ciliary basal body-plasma membrane docking, de novo centriole assembly involved in multi-ciliated epithelial cell differentiation, G2/M transition of mitotic cell cycle, mitotic cell cycle, positive regulation of centriole replication, protein phosphorylation, regulation of cytokinesis, regulation of G2/M transition of mitotic cell cycle, trophoblast giant cell differentiation
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GO - Molecular function (MF):
ATP binding, identical protein binding, protein serine/threonine kinase activity...
ATP binding, identical protein binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
centriole, centrosome, spindle pole, cytosol, nucleolus, nucleus, cleavage furrow, cytoplasm, deuterosome, XY body...
centriole, centrosome, spindle pole, cytosol, nucleolus, nucleus, cleavage furrow, cytoplasm, deuterosome, XY body
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polo like kinase 4
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 5 samples
Minimum 10 samples
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Kaplan plot for PLK4 in
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*NOTE: the Kaplan plots were collected from OncoLnc