NME4
Entrez ID: 4833
Full name: NME/NM23 nucleoside diphosphate kinase 4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: NDK
Chromosomal location: 16p13.3
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
Please click HERE
for better display.
NME4
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides...
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (PubMed:18635542, PubMed:17028143, PubMed:23150663).
View more >>
GO - Biological processes (BP):
CTP biosynthetic process, GTP biosynthetic process, lipid transport, nucleobase-containing small molecule interconversion, nucleoside metabolic process, purine nucleotide metabolic process, pyrimidine nucleotide metabolic process, regulation of apoptotic process, UTP biosynthetic process...
CTP biosynthetic process, GTP biosynthetic process, lipid transport, nucleobase-containing small molecule interconversion, nucleoside metabolic process, purine nucleotide metabolic process, pyrimidine nucleotide metabolic process, regulation of apoptotic process, UTP biosynthetic process
View more >>
GO - Molecular function (MF):
ATP binding, cardiolipin binding, metal ion binding, nucleoside diphosphate kinase activity...
ATP binding, cardiolipin binding, metal ion binding, nucleoside diphosphate kinase activity
View more >>
GO - Cellular component (CC):
mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial matrix, mitochondrion...
mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial matrix, mitochondrion
View more >>
NME/NM23 nucleoside diphosphate kinase 4
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for NME4 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc