RIOK3
Entrez ID: 8780
Full name: RIO kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: RIO: RIO3
Chromosomal location: 18q11.2
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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RIOK3
Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfer...
Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502). May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843).
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GO - Biological processes (BP):
cellular response to dsDNA, cellular response to dsRNA, cellular response to virus, chromosome segregation, defense response to virus, innate immune response, maturation of SSU-rRNA, negative regulation of I-kappaB kinase/NF-kappaB signaling, negative regulation of MDA-5 signaling pathway, negative ...
cellular response to dsDNA, cellular response to dsRNA, cellular response to virus, chromosome segregation, defense response to virus, innate immune response, maturation of SSU-rRNA, negative regulation of I-kappaB kinase/NF-kappaB signaling, negative regulation of MDA-5 signaling pathway, negative regulation of protein-containing complex assembly, positive regulation of innate immune response, positive regulation of interferon-beta production
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GO - Molecular function (MF):
ATP binding, caspase binding, metal ion binding, protein serine/threonine kinase activity...
ATP binding, caspase binding, metal ion binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, preribosome, small subunit precursor...
cytosol, preribosome, small subunit precursor
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RIO kinase 3
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A-loop
G-loop
αC-helix
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A-loop
G-loop
αC-helix
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Kaplan plot for RIOK3 in
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*NOTE: the Kaplan plots were collected from OncoLnc