MAP2K7
Entrez ID: 5609
Full name: mitogen-activated protein kinase kinase 7
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE7: MEK7
Chromosomal location: 19p13.2
Substructure location: Gatekeeper: 196 A-loop: 260...282 G-loop: [N/A] αC-helix: 157...172
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MAP2K7
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activa...
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074).
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GO - Biological processes (BP):
activation of JUN kinase activity, activation of MAPK activity, activation of protein kinase activity, apoptotic process, Fc-epsilon receptor signaling pathway, JNK cascade, positive regulation of ERK1 and ERK2 cascade, positive regulation of telomerase activity, positive regulation of telomere capp...
activation of JUN kinase activity, activation of MAPK activity, activation of protein kinase activity, apoptotic process, Fc-epsilon receptor signaling pathway, JNK cascade, positive regulation of ERK1 and ERK2 cascade, positive regulation of telomerase activity, positive regulation of telomere capping, positive regulation of telomere maintenance via telomerase, positive regulation of transcription, DNA-templated, regulation of mitotic cell cycle, response to heat, response to osmotic stress, response to tumor necrosis factor, response to UV, signal transduction, signal transduction by protein phosphorylation, stress-activated MAPK cascade, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, enzyme binding, JUN kinase kinase activity, magnesium ion binding, MAP kinase kinase activity, protein kinase binding, protein phosphatase binding, protein serine/threonine kinase activity, protein tyrosine kinase activity...
ATP binding, enzyme binding, JUN kinase kinase activity, magnesium ion binding, MAP kinase kinase activity, protein kinase binding, protein phosphatase binding, protein serine/threonine kinase activity, protein tyrosine kinase activity
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GO - Cellular component (CC):
cytosol, nucleus, cytoplasm...
cytosol, nucleus, cytoplasm
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mitogen-activated protein kinase kinase 7
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*NOTE: the Kaplan plots were collected from OncoLnc