BCKDK
Entrez ID: 10295
Full name: branched chain keto acid dehydrogenase kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: PDHK: BCKDK
Chromosomal location: 16p11.2
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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BCKDK
Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex....
Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
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GO - Biological processes (BP):
branched-chain amino acid catabolic process, cellular amino acid catabolic process, glucose homeostasis, negative regulation of pyruvate dehydrogenase activity, phosphorylation...
branched-chain amino acid catabolic process, cellular amino acid catabolic process, glucose homeostasis, negative regulation of pyruvate dehydrogenase activity, phosphorylation
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GO - Molecular function (MF):
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity, ATP binding, kinase activity, protein serine/threonine kinase activity...
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity, ATP binding, kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
mitochondrial alpha-ketoglutarate dehydrogenase complex, mitochondrial matrix, mitochondrion...
mitochondrial alpha-ketoglutarate dehydrogenase complex, mitochondrial matrix, mitochondrion
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branched chain keto acid dehydrogenase kinase
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
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Kaplan plot for BCKDK in
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*NOTE: the Kaplan plots were collected from OncoLnc