IKBKB
Entrez ID: 3551
Full name: inhibitor of nuclear factor kappa B kinase subunit beta
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: IKK
Chromosomal location: 8p11.21
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: 20...31 αC-helix: 52...67
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IKBKB
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:30337470). Acts as part of the canonical IKK complex in the conventional p...
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:30337470). Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation (PubMed:11297557, PubMed:15084260, PubMed:17213322, PubMed:19716809, PubMed:20410276, PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity).
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GO - Biological processes (BP):
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, cellular response to tumor necrosis factor, cortical actin cytoskeleton organization, Fc-epsilon receptor signaling pathway, I-kappaB kinase/NF-kappaB signaling, inflammatory response, innate immune resp...
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, cellular response to tumor necrosis factor, cortical actin cytoskeleton organization, Fc-epsilon receptor signaling pathway, I-kappaB kinase/NF-kappaB signaling, inflammatory response, innate immune response, interleukin-1-mediated signaling pathway, MyD88-independent toll-like receptor signaling pathway, negative regulation of apoptotic process, negative regulation of bicellular tight junction assembly, negative regulation of myosin-light-chain-phosphatase activity, peptidyl-serine phosphorylation, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of NF-kappaB transcription factor activity, positive regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, protein localization to plasma membrane, protein phosphorylation, regulation of establishment of endothelial barrier, regulation of phosphorylation, regulation of tumor necrosis factor-mediated signaling pathway, response to virus, stimulatory C-type lectin receptor signaling pathway, stress-activated MAPK cascade, T cell receptor signaling pathway, TRIF-dependent toll-like receptor signaling pathway, tumor necrosis factor-mediated signaling pathway, viral process
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GO - Molecular function (MF):
ATP binding, identical protein binding, IkappaB kinase activity, protein heterodimerization activity, protein homodimerization activity, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity, scaffold protein binding, transferrin receptor binding...
ATP binding, identical protein binding, IkappaB kinase activity, protein heterodimerization activity, protein homodimerization activity, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity, scaffold protein binding, transferrin receptor binding
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GO - Cellular component (CC):
cytosol, IkappaB kinase complex, nucleus, CD40 receptor complex, cytoplasmic side of plasma membrane, cytoplasm, membrane raft...
cytosol, IkappaB kinase complex, nucleus, CD40 receptor complex, cytoplasmic side of plasma membrane, cytoplasm, membrane raft
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inhibitor of nuclear factor kappa B kinase subunit beta
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Kaplan plot for IKBKB in
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*NOTE: the Kaplan plots were collected from OncoLnc