CASK
Entrez ID: 8573
Full name: calcium/calmodulin dependent serine protein kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: CASK
Chromosomal location: Xp11.4
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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CASK
Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor pro...
Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
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GO - Biological processes (BP):
calcium ion import, cell adhesion, negative regulation of cell-matrix adhesion, negative regulation of cellular response to growth factor stimulus, negative regulation of keratinocyte proliferation, negative regulation of wound healing, neurotransmitter secretion, positive regulation of calcium ion ...
calcium ion import, cell adhesion, negative regulation of cell-matrix adhesion, negative regulation of cellular response to growth factor stimulus, negative regulation of keratinocyte proliferation, negative regulation of wound healing, neurotransmitter secretion, positive regulation of calcium ion import, positive regulation of transcription by RNA polymerase II, regulation of synaptic vesicle exocytosis
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GO - Molecular function (MF):
ATP binding, calmodulin binding, guanylate kinase activity, neurexin family protein binding, protein serine/threonine kinase activity...
ATP binding, calmodulin binding, guanylate kinase activity, neurexin family protein binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
actin cytoskeleton, cytosol, basement membrane, nuclear lamina, nuclear matrix, nucleolus, basolateral plasma membrane, ciliary membrane, plasma membrane, presynaptic membrane, cell-cell junction, cytoplasm, focal adhesion, Schaffer collateral - CA1 synapse, vesicle...
actin cytoskeleton, cytosol, basement membrane, nuclear lamina, nuclear matrix, nucleolus, basolateral plasma membrane, ciliary membrane, plasma membrane, presynaptic membrane, cell-cell junction, cytoplasm, focal adhesion, Schaffer collateral - CA1 synapse, vesicle
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calcium/calmodulin dependent serine protein kinase
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αC-helix
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Kaplan plot for CASK in
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*NOTE: the Kaplan plots were collected from OncoLnc