AURKA
Entrez ID: 6790
Full name: aurora kinase A
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: Aur
Chromosomal location: 20q13.2
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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AURKA
Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome du...
Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis. Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735).
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GO - Biological processes (BP):
anaphase-promoting complex-dependent catabolic process, anterior/posterior axis specification, cell division, centrosome localization, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, G2/M transition of mitotic cell cycle, liver regeneration, mitotic cel...
anaphase-promoting complex-dependent catabolic process, anterior/posterior axis specification, cell division, centrosome localization, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, G2/M transition of mitotic cell cycle, liver regeneration, mitotic cell cycle, mitotic centrosome separation, mitotic spindle organization, negative regulation of apoptotic process, negative regulation of G2/M transition of mitotic cell cycle, negative regulation of gene expression, negative regulation of protein binding, neuron projection extension, peptidyl-serine phosphorylation, positive regulation of mitotic nuclear division, positive regulation of oocyte maturation, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein autophosphorylation, protein localization to centrosome, protein phosphorylation, regulation of centrosome cycle, regulation of cytokinesis, regulation of G2/M transition of mitotic cell cycle, regulation of protein stability, regulation of signal transduction by p53 class mediator, response to wounding, spindle assembly involved in female meiosis I, spindle organization, ubiquitin-dependent protein catabolic process
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GO - Molecular function (MF):
ATP binding, histone serine kinase activity, protein heterodimerization activity, protein kinase activity, protein kinase binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, ubiquitin protein ligase binding...
ATP binding, histone serine kinase activity, protein heterodimerization activity, protein kinase activity, protein kinase binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, ubiquitin protein ligase binding
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GO - Cellular component (CC):
centriole, centrosome, chromosome passenger complex, meiotic spindle, microtubule, microtubule cytoskeleton, mitotic spindle pole, spindle, spindle midzone, spindle pole centrosome, cytosol, condensed nuclear chromosome, centromeric region, germinal vesicle, nucleoplasm, nucleus, pronucleus, axon hi...
centriole, centrosome, chromosome passenger complex, meiotic spindle, microtubule, microtubule cytoskeleton, mitotic spindle pole, spindle, spindle midzone, spindle pole centrosome, cytosol, condensed nuclear chromosome, centromeric region, germinal vesicle, nucleoplasm, nucleus, pronucleus, axon hillock, cilium, midbody, perinuclear region of cytoplasm
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aurora kinase A
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Kaplan plot for AURKA in
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*NOTE: the Kaplan plots were collected from OncoLnc