GAK
Entrez ID: 2580
Full name: cyclin G associated kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: NAK: GAK
Chromosomal location: 4p16.3
Substructure location: Gatekeeper: 123 A-loop: 190...220, 222...225 G-loop: [N/A] αC-helix: 76...92
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GAK
Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1....
Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.
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GO - Biological processes (BP):
cell cycle, chaperone cofactor-dependent protein refolding, clathrin coat disassembly, clathrin-coated pit assembly, clathrin-dependent endocytosis, endoplasmic reticulum organization, Golgi organization, Golgi to lysosome transport, membrane organization, negative regulation of neuron projection de...
cell cycle, chaperone cofactor-dependent protein refolding, clathrin coat disassembly, clathrin-coated pit assembly, clathrin-dependent endocytosis, endoplasmic reticulum organization, Golgi organization, Golgi to lysosome transport, membrane organization, negative regulation of neuron projection development, protein localization to Golgi apparatus, protein localization to plasma membrane, receptor-mediated endocytosis, synaptic vesicle uncoating
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GO - Molecular function (MF):
ATP binding, chaperone binding, clathrin binding, cyclin binding, protein serine/threonine kinase activity...
ATP binding, chaperone binding, clathrin binding, cyclin binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, Golgi apparatus, cytoplasm, focal adhesion, intracellular membrane-bounded organelle, membrane, perinuclear region of cytoplasm, presynapse, vesicle...
cytosol, Golgi apparatus, cytoplasm, focal adhesion, intracellular membrane-bounded organelle, membrane, perinuclear region of cytoplasm, presynapse, vesicle
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cyclin G associated kinase
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Kaplan plot for GAK in
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*NOTE: the Kaplan plots were collected from OncoLnc