MUSK
Entrez ID: 4593
Full name: muscle associated receptor tyrosine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Musk
Chromosomal location: 9q31.3
Substructure location: Gatekeeper: 655 A-loop: 742...767 G-loop: [N/A] αC-helix: [N/A]
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MUSK
Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activat...
Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity).
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GO - Biological processes (BP):
memory, multicellular organism development, nervous system development, neuromuscular junction development, positive regulation of gene expression, positive regulation of kinase activity, positive regulation of MAPK cascade, positive regulation of neuron projection development, positive regulation o...
memory, multicellular organism development, nervous system development, neuromuscular junction development, positive regulation of gene expression, positive regulation of kinase activity, positive regulation of MAPK cascade, positive regulation of neuron projection development, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of protein geranylgeranylation, positive regulation of protein phosphorylation, protein autophosphorylation, regulation of MAPK cascade, regulation of synaptic growth at neuromuscular junction, skeletal muscle acetylcholine-gated channel clustering, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, metal ion binding, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity...
ATP binding, metal ion binding, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
integral component of plasma membrane, postsynaptic membrane, cell junction, neuromuscular junction, receptor complex...
integral component of plasma membrane, postsynaptic membrane, cell junction, neuromuscular junction, receptor complex
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muscle associated receptor tyrosine kinase
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*NOTE: the Kaplan plots were collected from OncoLnc