TRIM24
Entrez ID: 8805
Full name: tripartite motif containing 24
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: TIF1
Chromosomal location: 7q33-q34
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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TRIM24
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and ace...
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).
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GO - Biological processes (BP):
calcium ion homeostasis, cellular response to estrogen stimulus, negative regulation of cell population proliferation, negative regulation of transcription, DNA-templated, positive regulation of transcription, DNA-templated, protein autophosphorylation, protein catabolic process, protein ubiquitinat...
calcium ion homeostasis, cellular response to estrogen stimulus, negative regulation of cell population proliferation, negative regulation of transcription, DNA-templated, positive regulation of transcription, DNA-templated, protein autophosphorylation, protein catabolic process, protein ubiquitination, regulation of apoptotic process, regulation of protein stability, regulation of signal transduction by p53 class mediator, regulation of vitamin D receptor signaling pathway, transcription by RNA polymerase II
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GO - Molecular function (MF):
chromatin binding, estrogen response element binding, lysine-acetylated histone binding, nuclear receptor binding, p53 binding, protein kinase activity, signaling receptor binding, transcription coactivator activity, ubiquitin protein ligase activity, zinc ion binding...
chromatin binding, estrogen response element binding, lysine-acetylated histone binding, nuclear receptor binding, p53 binding, protein kinase activity, signaling receptor binding, transcription coactivator activity, ubiquitin protein ligase activity, zinc ion binding
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GO - Cellular component (CC):
cytosol, nuclear euchromatin, nucleoplasm, nucleus, perichromatin fibrils...
cytosol, nuclear euchromatin, nucleoplasm, nucleus, perichromatin fibrils
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tripartite motif containing 24
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Kaplan plot for TRIM24 in
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*NOTE: the Kaplan plots were collected from OncoLnc