EPHB6
Entrez ID: 2051
Full name: EPH receptor B6
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Eph
Chromosomal location: 7q34
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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EPHB6
Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression up...
Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
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GO - Biological processes (BP):
ephrin receptor signaling pathway, multicellular organism development, positive regulation of kinase activity, transmembrane receptor protein tyrosine kinase signaling pathway...
ephrin receptor signaling pathway, multicellular organism development, positive regulation of kinase activity, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, ephrin receptor activity, signaling receptor activity, transmembrane receptor protein tyrosine kinase activity...
ATP binding, ephrin receptor activity, signaling receptor activity, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
cytosol, extracellular region, integral component of plasma membrane, plasma membrane, receptor complex...
cytosol, extracellular region, integral component of plasma membrane, plasma membrane, receptor complex
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EPH receptor B6
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 5 samples
Minimum 10 samples
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Kaplan plot for EPHB6 in
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*NOTE: the Kaplan plots were collected from OncoLnc