PDPK1
Entrez ID: 5170
Full name: 3-phosphoinositide dependent protein kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: PDHK: PDHK
Chromosomal location: 16p13.3
Substructure location: Gatekeeper: 159 A-loop: 222...232, 239...247 G-loop: [N/A] αC-helix: 115...120
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PDPK1
Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 an...
Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca2+ entry and Ca2+-activated K+ channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages. Isoform 3 is catalytically inactive.
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GO - Biological processes (BP):
actin cytoskeleton organization, activation of protein kinase B activity, calcium-mediated signaling, cell migration, cellular response to brain-derived neurotrophic factor stimulus, cellular response to epidermal growth factor stimulus, cellular response to insulin stimulus, epidermal growth factor...
actin cytoskeleton organization, activation of protein kinase B activity, calcium-mediated signaling, cell migration, cellular response to brain-derived neurotrophic factor stimulus, cellular response to epidermal growth factor stimulus, cellular response to insulin stimulus, epidermal growth factor receptor signaling pathway, extrinsic apoptotic signaling pathway, Fc-epsilon receptor signaling pathway, focal adhesion assembly, hyperosmotic response, intracellular signal transduction, negative regulation of cardiac muscle cell apoptotic process, negative regulation of endothelial cell apoptotic process, negative regulation of neuron apoptotic process, negative regulation of protein kinase activity, negative regulation of toll-like receptor signaling pathway, negative regulation of transforming growth factor beta receptor signaling pathway, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, platelet activation, positive regulation of angiogenesis, positive regulation of blood vessel endothelial cell migration, positive regulation of phospholipase activity, positive regulation of protein localization to plasma membrane, positive regulation of release of sequestered calcium ion into cytosol, positive regulation of sprouting angiogenesis, positive regulation of vascular endothelial cell proliferation, protein autophosphorylation, protein phosphorylation, regulation of I-kappaB kinase/NF-kappaB signaling, regulation of mast cell degranulation, stimulatory C-type lectin receptor signaling pathway, T cell costimulation, T cell receptor signaling pathway, type B pancreatic cell development
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GO - Molecular function (MF):
3-phosphoinositide-dependent protein kinase activity, ATP binding, insulin receptor binding, phospholipase activator activity, phospholipase binding, protein kinase binding, protein serine/threonine kinase activity...
3-phosphoinositide-dependent protein kinase activity, ATP binding, insulin receptor binding, phospholipase activator activity, phospholipase binding, protein kinase binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, nucleus, plasma membrane, cell, cell projection, cytoplasm, cytoplasmic vesicle, focal adhesion, perikaryon, postsynaptic density...
cytosol, nucleus, plasma membrane, cell, cell projection, cytoplasm, cytoplasmic vesicle, focal adhesion, perikaryon, postsynaptic density
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3-phosphoinositide dependent protein kinase 1
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*NOTE: the Kaplan plots were collected from OncoLnc