IRAK2
Entrez ID: 3656
Full name: interleukin 1 receptor associated kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: IRAK
Chromosomal location: 3p25.3
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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IRAK2
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization....
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
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GO - Biological processes (BP):
activation of MAPK activity, cytokine-mediated signaling pathway, I-kappaB kinase/NF-kappaB signaling, inflammatory response, interleukin-1-mediated signaling pathway, intracellular signal transduction, JNK cascade, lipopolysaccharide-mediated signaling pathway, MyD88-dependent toll-like receptor si...
activation of MAPK activity, cytokine-mediated signaling pathway, I-kappaB kinase/NF-kappaB signaling, inflammatory response, interleukin-1-mediated signaling pathway, intracellular signal transduction, JNK cascade, lipopolysaccharide-mediated signaling pathway, MyD88-dependent toll-like receptor signaling pathway, negative regulation of NF-kappaB transcription factor activity, nucleotide-binding oligomerization domain containing signaling pathway, positive regulation of NF-kappaB transcription factor activity, protein phosphorylation, regulation of cytokine-mediated signaling pathway, response to interleukin-1, toll-like receptor 9 signaling pathway, toll-like receptor signaling pathway
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GO - Molecular function (MF):
ATP binding, protein heterodimerization activity, protein homodimerization activity, protein serine/threonine kinase activity...
ATP binding, protein heterodimerization activity, protein homodimerization activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, endosome membrane, nucleus, plasma membrane, cytoplasm...
cytosol, endosome membrane, nucleus, plasma membrane, cytoplasm
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interleukin 1 receptor associated kinase 2
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
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Kaplan plot for IRAK2 in
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*NOTE: the Kaplan plots were collected from OncoLnc