MAP3K13
Entrez ID: 9175
Full name: mitogen-activated protein kinase kinase kinase 13
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: MLK: LZK
Chromosomal location: 3q27.2
Substructure location: Gatekeeper: 233 A-loop: 296...318 G-loop: [N/A] αC-helix: [N/A]
Please click HERE
for better display.
MAP3K13
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphoryla...
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.
View more >>
GO - Biological processes (BP):
activation of JNKK activity, activation of JUN kinase activity, activation of MAPKK activity, JNK cascade, peptidyl-serine phosphorylation, positive regulation of axon extension, positive regulation of branching morphogenesis of a nerve, positive regulation of neuron maturation, positive regulation ...
activation of JNKK activity, activation of JUN kinase activity, activation of MAPKK activity, JNK cascade, peptidyl-serine phosphorylation, positive regulation of axon extension, positive regulation of branching morphogenesis of a nerve, positive regulation of neuron maturation, positive regulation of neuron projection arborization, positive regulation of NF-kappaB transcription factor activity, protein autophosphorylation, protein phosphorylation
View more >>
GO - Molecular function (MF):
ATP binding, enzyme binding, identical protein binding, IkappaB kinase complex binding, JUN kinase kinase kinase activity, MAP kinase kinase kinase activity, metal ion binding, protein homodimerization activity, protein kinase binding, protein serine/threonine kinase activity...
ATP binding, enzyme binding, identical protein binding, IkappaB kinase complex binding, JUN kinase kinase kinase activity, MAP kinase kinase kinase activity, metal ion binding, protein homodimerization activity, protein kinase binding, protein serine/threonine kinase activity
View more >>
GO - Cellular component (CC):
cytoplasm, membrane...
cytoplasm, membrane
View more >>
mitogen-activated protein kinase kinase kinase 13
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for MAP3K13 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc