DAPK3
Entrez ID: 1613
Full name: death associated protein kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: DAPK: DAPK
Chromosomal location: 19p13.3
Substructure location: Gatekeeper: 93 A-loop: 160...182 G-loop: 19...25 αC-helix: 49...51
Please click HERE
for better display.
DAPK3
Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autoph...
Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca2+ and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor.
View more >>
GO - Biological processes (BP):
apoptotic process, apoptotic signaling pathway, cellular response to interferon-gamma, chromatin organization, intracellular signal transduction, negative regulation of translation, neuron differentiation, positive regulation of apoptotic process, positive regulation of canonical Wnt signaling pathw...
apoptotic process, apoptotic signaling pathway, cellular response to interferon-gamma, chromatin organization, intracellular signal transduction, negative regulation of translation, neuron differentiation, positive regulation of apoptotic process, positive regulation of canonical Wnt signaling pathway, positive regulation of cell migration, positive regulation of extrinsic apoptotic signaling pathway in absence of ligand, protein autophosphorylation, protein phosphorylation, regulation of actin cytoskeleton reorganization, regulation of apoptotic process, regulation of autophagy, regulation of cell motility, regulation of cell shape, regulation of focal adhesion assembly, regulation of mitotic cell cycle, regulation of mitotic nuclear division, regulation of myosin II filament organization, regulation of smooth muscle contraction, regulation of transcription, DNA-templated
View more >>
GO - Molecular function (MF):
ATP binding, cAMP response element binding protein binding, identical protein binding, leucine zipper domain binding, protein C-terminus binding, protein homodimerization activity, protein serine/threonine kinase activity, Rho GTPase binding...
ATP binding, cAMP response element binding protein binding, identical protein binding, leucine zipper domain binding, protein C-terminus binding, protein homodimerization activity, protein serine/threonine kinase activity, Rho GTPase binding
View more >>
GO - Cellular component (CC):
actin filament, nucleoplasm, nucleus, PML body, cytoplasm, membrane raft...
actin filament, nucleoplasm, nucleus, PML body, cytoplasm, membrane raft
View more >>
death associated protein kinase 3
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for DAPK3 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc