BUB1
Entrez ID: 699
Full name: BUB1 mitotic checkpoint serine/threonine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: BUB
Chromosomal location: 2q13
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: 793...799 αC-helix: 828...840
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BUB1
Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization o...
Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.
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GO - Biological processes (BP):
apoptotic process, cell division, cell population proliferation, meiotic sister chromatid cohesion, centromeric, mitotic cell cycle checkpoint, mitotic spindle assembly checkpoint, regulation of chromosome segregation, regulation of sister chromatid cohesion, viral process...
apoptotic process, cell division, cell population proliferation, meiotic sister chromatid cohesion, centromeric, mitotic cell cycle checkpoint, mitotic spindle assembly checkpoint, regulation of chromosome segregation, regulation of sister chromatid cohesion, viral process
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GO - Molecular function (MF):
ATP binding, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, condensed nuclear chromosome kinetochore, condensed nuclear chromosome outer kinetochore, nucleoplasm, condensed chromosome kinetochore, kinetochore, membrane...
cytosol, condensed nuclear chromosome kinetochore, condensed nuclear chromosome outer kinetochore, nucleoplasm, condensed chromosome kinetochore, kinetochore, membrane
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BUB1 mitotic checkpoint serine/threonine kinase
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 5 samples
Minimum 10 samples
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Kaplan plot for BUB1 in
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*NOTE: the Kaplan plots were collected from OncoLnc